Results 41 to 50 of about 1,455,080 (181)

COVID-19 and Fulminant Clostridium difficile Colitis Co-Infection

European Journal of Case Reports in Internal Medicine, 2021
The development of Clostridium difficile infection in COVID-19 patients is an understudied complication of the disease. Herein, we present the case of a 46-year-old man who developed severe healthcare-associated C.
Abdul Ahad Ehsan Sheikh, Abu Baker Sheikh, Ishan Shah, Ali Hamza Khair, Nismat Javed, Rahul Shekhar   +5 more
doaj   +1 more source

Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis

Case Reports in Gastroenterology, 2013
We present a rare case of toxic megacolon accompanied by necrosis of the colon due to chronic dilation caused by stenosis of the sigmoid colon as a complication of diverticulitis.
P. Antonopoulos, M. Almyroudi, V. Kolonia, S. Kouris, N. Troumpoukis, N. Economou   +5 more
doaj   +1 more source

Outcome of Toxic Megacolon during Pregnancy

Canadian Journal of Gastroenterology, 1990
Two patients with ulcerative colitis required subtotal colectomy and ileostomy for toxic megacolon during pregnancy. Subsequently, a mucosal proctectomy with ileal pouch-anal anastomosis was performed. These two patients who avoided permanent ileostomies
Carl Chartrand-Lefebvre, Jacques Heppell, Claude Potvin, Richard Clermont, Alfons Pomp   +4 more
doaj   +1 more source

Toxic megacolon associated with Clostridium difficile infection recurrence: a case report complicated by multiple bacterial infections and successfully treated with oral fidaxomicin

Clinical Management Issues, 2014
Toxic megacolon is a severe complication of Clostridium difficile infection (CDI) with a high percentage of mortality. The mainstay of treatment is currently represented by medical management, while surgical intervention is indicated in patients not ...
Addolorata Masiello, Mario Magliocca, Giuseppina Dell’Aquila, Patrizia Maio, Sergio Giglio, Nicola Acone   +5 more
doaj   +1 more source

Severe Clostridium difficile infections in intensive care units: Diverse clinical presentations

Journal of Microbiology, Immunology and Infection, 2021
Background: Clostridium difficile infections (CDIs) cause significant mortality and morbidity. Critically ill patients are susceptible to CDIs and tend to have severe CDIs, and their clinical presentations are not merely diarrhea.
Jen-Chieh Lee, Yuan-Pin Hung, Bo-Yang Tsai, Pei-Jane Tsai, Wen-Chien Ko   +4 more
doaj   +1 more source

Toxic megacolon: a potentially lethal condition. Case report

Journal of Surgical Case Reports
Toxic megacolon denotes an abrupt non-obstructive distension of the colon, accompanied by systemic signs of toxicity. Mortality rates can soar as high as 7.9%.
José Jesús Fabián-Méndez, Q. Torres-Salazar   +1 more
semanticscholar   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Preliminary non‐comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate

Veterinary Record, Volume 198, Issue 3, Page e101-e107, 31 January/7 February 2026.
Abstract Background Challenges associated with bowel cleansing protocols for canine colonoscopy include practical applicability and inadequate preparations. This study aimed to describe and evaluate an adapted protocol to simplify colonoscopy preparation in dogs.
Julia Elia da Silva Paranhos, Melissa Guillen Gonçalves de Souza, Daniela Araujo de Sousa, Debora Costabile Soibelman, Sabrina Martins da Costa Ferreira, Juliana da Silva Leite, Bruno Penna, Ana Maria Reis Ferreira   +7 more
wiley   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Gaps Between European Crohn's Colitis Organisation Quality Standards of Care and the Real World in Special Situations in Inflammatory Bowel Disease Across Europe: Results From E‐QUALITY Survey

JCC Plus, Volume 1, Issue 1, January 2026.
ABSTRACT Background Managing special situations in Inflammatory Bowel Disease (IBD)—such as surgery, nutrition, acute severe ulcerative colitis (ASUC) and paediatric‐to‐adult transition—is critical for patient outcomes. The European Crohn's and Colitis Organisation's (ECCO) E‐QUALITY initiative aimed to identify gaps between its evidence‐based care ...
Gionata Fiorino, Catarina Fidalgo, Michel Adamina, Manuel Barreiro‐de Acosta, Mariam P. Ali, Martin Bortlik, Johan Burisch, Axel Dignass, David Drobne, Omar Faiz, Marc Ferrante, Liselotte Fierens, Lihi Godny, Anna Gojdicova, Marietta Iacucci, Susanna Jӓghult, Konstantinos Karmiris, Julien Kirchgesner, Sophie Restellini, Francesca Rosini, Dror Shouval, Henit Yanai, Edyta Zagórowicz, Alissa Walsh, on behalf of European Crohn's Colitis Organisation   +24 more
wiley   +1 more source