Results 131 to 140 of about 672,002 (339)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Management of chromium(VI)-contaminated soils through synergistic application of vermicompost, chromate reducing rhizobacteria and Arbuscular mycorrhizal fungi (AMF) reduced plant toxicity and improved yield attributes in Ocimum basilicum L. [PDF]
, 2022 Sumit K. Soni +2 more
openalex +1 more source
Earthworm abundances in endophyte-infected tall fescue pastures in Northwest Arkansas [PDF]
, 2008 The ecology of organisms that co-evolve within an ecosystem is likely to be distinct from that involving organisms recently introduced into an area. To better understand the relationship of earthworms with endophyte-infected tall fescue, earthworms in ...
Rashe, Ashley, Savin, Mary C.
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Investigation of α and β - Thujone Content in Common Wormwood from Iran
Journal of Medicinal Plants, 2008 Background: Artemisia absinthium L. (common wormwood) has been widely used in traditional medicine. The plant contains toxic components: α and β-thujone, therefore, it should be used with caution.
H Hajimehdipoor +5 more
doaj
Applied Biological ChemistryConsumption of wild plants is a common practice globally; however, not all plants are safe for human consumption, as some are toxic. Toxic plants often resemble edible species, which makes their identification difficult, particularly for non-experts ...
Su Yeon Kim, Cheol Seong Jang
doaj +1 more source
Cancer in Auto Factories [PDF]
, 2009 This article is part of the collection of writings of Marshall (Mike) Westfall, retired autoworker from General Motors in Flint, Michigan (1964-1994) and activist critic of the auto industry restructuring that led to devastating job losses. It originally
Westfall, Marshall (Mike)
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source