Results 71 to 80 of about 597,759 (309)
BiocharBiochar-derived dissolved organic matter (DOM) is a highly active component that plays a critical and complex role in the immobilization of heavy metals.
Fuxiang Zhang +6 more
doaj +1 more source
ToxicsOtotoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the ...
Gregory M. Zarus +6 more
doaj +1 more source
On-chip spectroscopy with thermally-tuned high-Q photonic crystal cavities
, 2015 Spectroscopic methods are a sensitive way to determine the chemical composition of potentially hazardous materials. Here, we demonstrate that thermally-tuned high-Q photonic crystal cavities can be used as a compact high-resolution on-chip spectrometer ...
Andreas C. Liapis +5 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Progress on internal exposure to typical environmental persistent organic pollutants and cancer
环境与职业医学Environmental pollution is closely linked to the occurrence and development of cancer. Chemical carcinogens are the most important environmental factors causing cancer in humans. Among them, persistent organic pollutants (POPs) are characterized by their
Xuerui MA +5 more
doaj +1 more source
How does the WFD address cumulative stress (including mixture toxicity) of pollutants to achieve good chemiscal and ecological status of water bodies? [PDF]
, 2011 It is now more than ten years ago that the Water Framework Directive (WFD) was adopted by the European Parliament. The main objectives of the WFD are (i) to achieve good ecological and chemical status for inland surface waters, transitional waters and ...
Brock, T.C.M.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ecotoxicology and Environmental SafetyBisphenol M (BPM), a structural analog of bisphenol A (BPA) commonly used in food packaging and consumer plastics, remains incompletely characterized in terms of its obesogenic potential and underlying molecular mechanisms, posing challenges for evidence-
Xin Wang +6 more
doaj +1 more source
Migration of contaminants from food packages to its content – Brazilian scenario and regulation [PDF]
, 2018 Consumers demand pleasant taste and odor in the final food product. Changes in these characteristics may be due to food deterioration or migration of substances from the packaging into food.
Concenço, F. I. (Fernanda) +3 more
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