Results 11 to 20 of about 33,767 (165)

Systemic immune changes accompany combination treatment with immunotoxin LMB‐100 and nab‐paclitaxel

Cancer Medicine, Volume 12, Issue 4, Page 4236-4249, February 2023., 2023
LMB‐100 is an immunotoxin directed against mesothelin, a surface protein expressed by over 85% of pancreatic adenocarcinomas as well as an estimated 30% of all solid tumors. Immunotoxin therapies, while potentially promising, are limited by their side effect profiles, most notably capillary leak syndrome (CLS).
Guillaume Joe Pegna, Min‐Jung Lee, Cody J. Peer, Mehwish I. Ahmad, David J. Venzon, Yunkai Yu, Akira Yuno, Seth M. Steinberg, Liang Cao, William D. Figg, Renee N. Donahue, Raffit Hassan, Ira Pastan, Jane B. Trepel, Christine Alewine   +14 more
wiley   +1 more source

Roundup causes high levels of mortality following contact exposure in bumble bees

Journal of Applied Ecology, Volume 58, Issue 6, Page 1167-1176, June 2021., 2021
Surfactants, or other co‐formulants, in herbicides and other pesticides may contribute to global bee declines. We recommend that, as a precautionary measure until co‐formulant identities are made public, label guidelines for all pesticides be altered to explicitly prohibit application to plants when bees are likely to be foraging on them.
Edward A. Straw, Edward N. Carpentier, Mark J. F. Brown   +2 more
wiley   +1 more source

Real‐World Survival in Patients with Metastatic Melanoma after Discontinuation of Anti‐PD‐1 Immunotherapy for Objective Response or Adverse Effects: A Retrospective Study

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
Objective. Anti‐PD‐1 has dramatically improved the survival of patients with advanced melanoma. However, there is a lack of data on maintenance of the response after treatment discontinuation. We aimed to evaluate the progression‐free survival (PFS) of patients with metastatic melanoma after anti‐PD‐1 interruption for objective response (OR) or ...
Julie Valentin, Thomas Ferté, Valérie Dorizy-Vuong, Léa Dousset, Sorilla Prey, Caroline Dutriaux, Anne Pham-Ledard, Marie Beylot-Barry, Emilie Gérard, Nihal Ahmad   +9 more
wiley   +1 more source

Review of the methods to determine the hazard and toxicity of pesticides to bumblebees [PDF]

, 2001
Methods to determine the impact of pesticides on bumblebees are described. They are classified into laboratory tests to determine the acute toxicity and the hazard to bumblebees, (semi) field tests, and brood tests.
Steen, J.J.M., van der
core   +5 more sources

History and sensitivity comparison of two standard whole-sediment toxicity tests with crustaceans : the amphipod Hyalella azteca and the ostracod Heterocypris incongruens microbiotest [PDF]

, 2015
The review first details the development of the test procedures with Hyalella azteca which historically emerged as one of the recommended test species for whole-sediment assays and its gradual standardization and endorsement by national and international
Blaise, C, De Cooman, W, Detemmerman, L, Elst, R, Janssen, Colin, Persoone, Guido   +5 more
core   +2 more sources

La prévalence des pathologies de la surface oculaire chez les patients glaucomateux

Journal de la Société Marocaine d’Ophtalmologie, 2018
Les patients glaucomateux ont souvent besoin d’un traitement local hypotonisant pendant de nombreuses années. Cette administration chronique des collyres a été impliquée dans la survenue des pathologies de la surface oculaire.
H. Oulehri, F. Chraïbi, M. Abdellaoui, I. Benatiya   +3 more
doaj   +1 more source

The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases

Frontiers in Molecular Biosciences, 2020
The motor neurodegenerative disease spinal muscular atrophy (SMA) is caused by alterations of the survival motor neuron 1 (SMN1) gene involved in RNA metabolism.
Delphine Sapaly, Perrine Delers, Jennifer Coridon, Badih Salman, Franck Letourneur, Florent Dumont, Suzie Lefebvre   +6 more
doaj   +1 more source

Détermination du niveau de toxicité des sédiments de rivière par le test de bioluminescence bactérienne [PDF]

, 1991
A partir de références bibliographiques encore réduites, les auteurs ont mis au point un protocole expérimental d'évaluation de la toxicité des sédiments de rivière, après extraction au dichlorométhane et mesure de la toxicité par le lest de ...
Bonnefille, M., Larbaitgt, G., Peyre, D., Tabonet, A.   +3 more
core   +1 more source

Biocapteurs pour le contrôle de la toxicité des eaux : application des bioélectrodes algales [PDF]

, 1992
L'amélioration de la qualité de l'environnement passe par la réalisation de contrôles de toxicité in situ et en continu des sources de pollution ou des milieux contaminés, à l'aide de systèmes automatisés à réponse rapide.
Pandard, P., Vasseur, P.
core   +1 more source

Interspecific trait integration increases with environmental harshness: A case study along a metal toxicity gradient

Functional Ecology, Volume 34, Issue 7, Page 1428-1437, July 2020., 2020
A free Plain Language Summary can be found within the Supporting Information of this article Abstract Functional traits are commonly used to calculate a wide array of functional diversity indices to infer different mechanisms of community assembly and species coexistence.
Guillaume Delhaye, David Bauman, Maxime Séleck, Edouard Ilunga wa Ilunga, Grégory Mahy, Pierre Meerts, Marko Spasojevic   +6 more
wiley   +1 more source