Results 91 to 100 of about 1,892,256 (250)

Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients

Stem Cell Research
Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient ...
Xuan Xu, Bing Xue, Dingqi Zhang, Yupeng Wang, Bonan Chen, Zhenghua Shan, Wenzhuo Zhao, Tianxiao Qiu, Jing Sun, Shengying Qin   +9 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The toxicity of perfluoroalkyl acids in zebrafish (Danio rerio) [PDF]

, 2013
Perfluoroalkyl acids (PFAAs) are globally distributed synthetic chemicals. Their unique properties make them widely used, in industry and elsewhere. These are a group of compounds with varying carbon chain lengths and functional groups.
Ul Haq, Mazhar
core   +1 more source

Lab resource: single cell line generation of an induced pluripotent stem cell line UJSi006-A from a patient with ultra-treatment-resistant schizophrenia

Stem Cell Research
Ultra-treatment-resistant schizophrenia (UTRS) is the most severe subtype of treatment refractoriness, with persistent symptoms despite clozapine use.
Dingqi Zhang, Yupeng Wang, Bonan Chen, Zhenghua Shan, Tianxiao Qiu, Wenzhuo Zhao, Zepeng Wang, Xuan Xu, Bing Xue, Jing Sun, Aiming Gu, Shengying Qin   +11 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.
Barbara D. Abbott, Carmen R. Wood, Andrew M. Watkins, Kaberi P. Das, Christopher S. Lau   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DETECTIVE: Detection of Endpoints and Biomarkers for Repeated Dose Toxicity using in vitro Systems

, 2022
136165Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes.
Stöber, R., Water, B. van de, Jennings, P., Peterson, H., Widera, A., Hengstler, J., Ringwald, A., Sickmann, A., Hescheler, J., Sachinidis, A., Kleinjans, J., Hammad, S., Reif, R., Escher, S., Rogiers, V., Spitkovsky, D., Limonciel, A., Keun, H., Kopp-Schneider, A., Vinken, M., Wink, S.   +20 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Obesogenic effects of perinatal bisphenol AF exposure on prepubertal male offspring rats

Shanghai yufang yixue
ObjectiveTo investigate the disruptive effects of perinatal exposure to the environmental endocrine disruptor bisphenol AF (BPAF) on hepatic lipid metabolism in prepubertal (postnatal day 21, PND21) male offspring rats, and to provide scientific evidence
LIU Xi, YANG Zhengli, CHENG Xueqing, YANG Jun, XU Jing, HONG Xinyu   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source