Results 71 to 80 of about 2,971,993 (317)

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Polycyclic Aromatic Hydrocarbons: Sources, Toxicity, and Remediation Approaches

Frontiers in Microbiology, 2020
Polycyclic aromatic hydrocarbons (PAHs) are widespread across the globe mainly due to long-term anthropogenic sources of pollution. The inherent properties of PAHs such as heterocyclic aromatic ring structures, hydrophobicity, and thermostability have ...
A. Patel, Shabnam S Shaikh, Kunal R. Jain, C. Desai, D. Madamwar   +4 more
semanticscholar   +1 more source

Head-specific transcriptomic profiles associated with chronic exposure to lambda-cyhalothrin and spinetoram during larval stage in honey bees (Apis mellifera)

Applied Biological Chemistry
Pesticide exposure during larval development can cause long-lasting impairments in honey bees; however, the underlying molecular mechanisms remain unclear.
Bala Murali Krishna Vasamsetti, Hyunjun Lee, Kyongmi Chon, Juyeong Kim, Bo-Seon Kim, Chang-Young Yoon, Sojeong Hwang, Minju Choi, Hui-Yeon Ahn, Kyeong-Hun Park   +9 more
doaj   +1 more source

Hydrophobic Sand Is a Non-Toxic Method of Urine Collection, Appropriate for Urinary Metal Analysis in the Rat

Toxics, 2017
Hydrophobic sand is a relatively new method of urine collection in the rodent, comparable to the established method using a metabolic cage. Urine samples are often used in rodent research, especially for biomarkers of health changes after internal ...
Jessica F. Hoffman, Vernieda B. Vergara, Steven R. Mog, John F. Kalinich   +3 more
doaj   +1 more source

Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan, Lindsay A. Renfro, Yue Wu, Katia M. Crisler, Erin Marcotte, Tanya Trippett, Terzah Horton, Bradford S. Hoppe, Frank G. Keller, Chris Forlenza, Cindy Schwartz, Kara M. Kelly, Peter D. Cole, Sharon M. Castellino, Justine M. Kahn   +14 more
wiley   +1 more source

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

International Journal of Environmental Research and Public Health, 2020
Lead (Pb) toxicity has been a subject of interest for environmental scientists due to its toxic effect on plants, animals, and humans. An increase in several Pb related industrial activities and use of Pb containing products such as agrochemicals, oil ...
Ajay Kumar, Ajay Kumar, Cabral-Pinto M.M.S., A. Chaturvedi, A. Shabnam, G. Subrahmanyam, Raju Mondal, D. Gupta, S. K. Malyan, Smita S. Kumar, Shakeel A. Khan, K. Yadav   +11 more
semanticscholar   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Mitochondrial Toxicity [PDF]

Toxicological Sciences, 2018
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creating a large number of potential gene-environment interactions in mitochondrial toxicity.
Meyer, Joel N, Hartman, Jessica H, Mello, Danielle F   +2 more
openaire   +2 more sources

Tracking Health Related Quality of Life From Diagnosis to Follow‐Up Among Australian Children With Acute Lymphoblastic Leukaemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows, Clarissa E. Schilstra, Karen McCleary, Nancy E. Briggs, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla‐Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Toby Trahair, Marion K. Mateos, Joanna E. Fardell   +19 more
wiley   +1 more source

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

Journal of Immunotherapy for Cancer, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
I. Puzanov, A. Diab, K. Abdallah, C. Bingham, C. Brogdon, R. Dadu, L. Hamad, S. Kim, M. Lacouture, N. Leboeuf, D. Lenihan, C. Onofrei, V. Shannon, R. Sharma, A. Silk, D. Skondra, M. Suarez‐Almazor, Y. Wang, K. Wiley, H. Kaufman, M. Ernstoff, Jeff Deborah Stephanie Joan Janie Daniel David Ion Rena Anderson Arrindell Andrews Ballesteros Boyer Chen , J. Anderson, Deborah Arrindell, S. Andrews, J. Ballesteros, J. Boyer, Daniel S Chen, David Chonzi, I. Cotarla, R. Cunha, M. Davies, M. Dawson, A. Dicker, L. Eifler, Andrew D. Ferguson, C. Ferlini, S. Frankel, W. Go, Celestine G. Gochett, J. Goldberg, P. Goncalves, T. Goswami, Nancy C. Gregory, J. Gulley, V. Hayreh, Nicole Helie, William C. Holmes, Jer-Yuan hsu, R. Ibrahim, C. Larocca, K. Lehman, S. Ley-Acosta, O. Lambotte, J. Luke, J. Mcclure, Elisabete Michelon, Mary C. Nakamura, K. Patel, B. Piperdi, Z. Rasheed, D. Reshef, J. Riemer, C. Robert, M. Sarkeshik, Ann Saylors, J. Schreiber, K. Shafer-Weaver, W. Sharfman, E. Sharon, R. Sherry, C. Simonson, C. Thomas, John A Thompson, E. Trehu, D. Tresnan, M. Turner, Darshan Wariabharaj, I. Waxman, L. Wood, Lin Zhang, P. Zheng   +81 more
semanticscholar   +1 more source