Results 151 to 160 of about 409,767 (250)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Toxicity Profile of <i>Plectranthus glandulosus</i> Hook. F. (Lamiaceae) Aqueous Extract, Hydro-Ethanolic Extract, and Ethyl Acetate Fraction. [PDF]

Biochem Res Int
Zouheira D, Nchouwet ML, Nfor NG, Daïrou H, Romuald J, Vandi T, Poualeu Kamani SL, Tchamgoue AD, Tchokouaha Yamthe LR, Wansi Ngnokam SL, Agbor GA.   +10 more
europepmc   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

The Genetic and Embryo-Fetal Developmental Toxicity Profile of the Novel Transgelin Agonist Deg-AZM: Ames, Micronucleus, Chromosomal Aberration, and Rat EFD Studies. [PDF]

Biomedicines
Gu X, Xu Y, Liu N, Li K, Wang X, Zhang J, Zhang X, Ding Y, Li X, Zhou H, Ai X, Yang C.   +11 more
europepmc   +1 more source

Acetoacetates Derived From Vegetable Oils: A Platform for Tailor‐Made Vinylogous Urethane Foams

Advanced Functional Materials, EarlyView.
A renewable vegetable oil is converted into acetoacetate‐functionalized precursors for the preparation of catalyst‐free vinylogous urethane foams. Room‐temperature foaming with n‐pentane generates lightweight cellular materials, while the choice of amine enables control over foam structure and mechanical properties.
Krzysztof Polaczek, Priscilla de Souza Lima, Olga Gotkiewicz, Ondrej Kopilec, Radka Hobzova, Lívia Kanizsová, Mikelis Kirpluks, Ondrej Sedlacek, Hynek Beneš   +8 more
wiley   +1 more source

Efficacy and Toxicity Profile of Carboplatin/Gemcitabine Chemotherapy in Locally Advanced or Metastatic Biliary Tract Cancer: A Single UK Centre Experience. [PDF]

Cancers (Basel)
Baraka B, Ponda DJ, Hanna J, Gomez D, Aithal G, Arora A.   +5 more
europepmc   +1 more source

Photo‐Switchable Molecular Module Programming PET Biodegradation in Aquatic Environments

Advanced Functional Materials, EarlyView.
We address the plastic durability paradox by integrating an itaconic acid–derived pyrrolidone module into polymer backbones. Sunlight in water triggers Norrish Type I ring‐opening and hydrophilization, enabling rapid biodegradation into nontoxic minerals.
Mohammad Asif Ali, Jixin Zheng, Satoshi Wakai, Jie Liu, Hidetaka Nomaki, Misato Tsukatani, Noriyuki Isobe, Jingcheng Sang, Yuriko Aoki, Hideo Okamura, Daisuke Sasaki, Chiaki Ogino, Yuzo Yamazaki, Takashi Nishikaze, Kenji Takada, Maiko K. Okajima, Tatsuo Kaneko   +16 more
wiley   +1 more source

Cardiovascular Toxicity Profile of Macrolides Investigated Using VigiBase Data: A Pharmacovigilance Study. [PDF]

Cardiovasc Toxicol
Kono Y, Niimura T, Goda M, Ueta S, Kawada K, Miyata K, Aizawa F, Yagi K, Izawa-Ishizawa Y, Ishizawa K.   +9 more
europepmc   +1 more source

From Bulk to Colloidal Nanocrystals: Top‐Down Synthesis of Highly Luminescent Cs2ZrCl6:Te4+ Double Perovskite Nanocrystals for X‐Ray Imaging

Advanced Functional Materials, EarlyView.
Top‐down ultrasonication produces highly emissive Cs2ZrCl6:Te4+ nanocrystals (NCs) with a PLQY of 65%, which is higher compared to that of the NCs synthesized by typical bottom‐up hot‐injection synthesis. The colloidal Cs2ZrCl6:Te4+ NCs have been found to be potential candidates for x‐ray scintillation imaging.
Yang Liu, Ye Wu, Hongpeng Liu, Cong Cui, Iago López‐Fernández, Nadesh Fiuza‐Maneiro, Sergio Gómez‐Graña, Yingjun Chai, Zhicheng Wang, Yusheng Wu, Laishi Li, Xiaoming Li, Lakshminarayana Polavarapu   +12 more
wiley   +1 more source

Evaluation of the Toxicity Profile and Central Nervous System Activities of Glue (Adhesive) Inhalation in Wistar Rats. [PDF]

J Toxicol
Jimoh AO, Hudu SA, Ibeabuchi OE, Abubakar B, Umaru ML, Sani Z, Otalike EG, Mohammed U, Haruna MS, Adeshina KA.   +9 more
europepmc   +1 more source