Results 151 to 160 of about 742,766 (263)

A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats

Journal of Pharmacopuncture, 2015
Jinhee Kim, Jongcheol Lee, Sungchul Kim
doaj   +1 more source

Evaluation of the avian acute oral and sub-acute dietary toxicity test for pesticide registration. [PDF]

Regul Toxicol Pharmacol, 2019
Hilton GM, Odenkirchen E, Panger M, Waleko G, Lowit A, Clippinger AJ.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Comparison of false-positive rates of 2 hypothesis-test approaches in relation to laboratory toxicity test performance. [PDF]

Environ Toxicol Chem, 2019
Fox JF, Denton DL, Diamond J, Stuber R.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Investigation of the photocatalytic activity of magnetically recoverable g-C₃N₄/CoFe₂O₄/Bi₂MoO₆ particles for purifying tetracycline antibiotics: synthesis, characterization, ecotoxicity analysis, and plant toxicity test. [PDF]

RSC Adv
Tang Z, Hu C, Zhang R, Yu J, Cai L, Yang Z, Wang X, Wu S, Liu D.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements. [PDF]

J Toxicol, 2018
Srinivasa Rao B, Chandrasekaran CV, Srikanth HS, Sasikumar M, Edwin Jothie R, Haseena B, Bharathi B, Selvam R, Prashanth D.   +8 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Prevalidation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model. [PDF]

Appl In Vitro Toxicol, 2018
Jackson GR, Maione AG, Klausner M, Hayden PJ.   +3 more
europepmc   +1 more source