John William Trevan’s concept of Median Lethal Dose (LD50/LC50) – more misused than used [PDF]
Journal of Pre-Clinical and Clinical Research, 2021 Introduction Median lethal dose (MLD) has been a controversial subject among biologists and animal ethicists since its inception in 1927 by Trevan. Toxicologists use MLD (LD50) as the first step to assess the toxicity of a substance.
Sadasivan Kalathil Pillai +5 more
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Components and acute toxicity of nanoherbal haramonting (Rhodomyrtus tomentosa) [PDF]
Journal of HerbMed Pharmacology, 2021 Introduction: Rhodomyrtus tomentosa (haramonting), a typical plant of North Sumatera, Indonesia, contains important medicinal ingredients. Nano sized drugs have high loading capacities and can be given at high concentrations.
Putri Cahaya Situmorang +3 more
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LD50 Acute Toxicity Test of the Anticancer Compound of Dibutyltin (IV) Bis-N-Benzyl Methyl Dithiocarbamate in White Mouse (Mus musculus) [PDF]
Asia Pacific Journal of Medical Toxicology, 2023 Organotin compounds are organometallic compounds composed of one or more tin-carbon (Sn-C) bonds. Organotin compounds have been shown to have anticancer, antibacterial, and antitumor activities.
Mukhlis Sanuddin +5 more
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USING OF AQUATIC EXTRACTS OF SALVIA OFFICINALIS TO CONTROL THE SNAIL BULINUS TRUNCATUS THE INTERMEDIATE HOST OF SCHISTOSOMIASIS IN IRAQ (PART I) [PDF]
Basrah Journal of Veterinary Research, 2016 Samples of the snails were collected from site in Al-Rasheed distract (30 km) southern ofBaghdad. Isolation, identification and acclimatization to laboratory circumstances made within thelaboratory.
Mohammed J.L. Al-Obaidi +3 more
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Cogent Food & Agriculture, 2020 The study evaluates the toxic effects of acute and sub-acute oral administration of methanol extracts of Geophila obvallata in rats. During acute study, a dose of 1600, 2900 and 5000 mg/kg bw of extract was orally administered to rats. Rats were observed
Osafanme Lucky Iserhienrhien +1 more
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A statistical evaluation of the effects of gender differences in assessment of acute inhalation toxicity [PDF]
, 2011 Acute inhalation toxicity of chemicals has conventionally been assessed by the median lethal concentration (LC50) test (organisation for economic co-operation and development (OECD) TG 403).
Price, Charlotte +13 more
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The LD50-The Beginning of the End [PDF]
, 1983 It has long been recognized that the LD50 measure (usually conducted using rats or mice) provides only a rough estimate of the acute toxicity of a chemical in humans.
Rowan, Andrew N.
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Acute Toxicity of Quercetin From Onion Skin in Mice
Pharmaceutical and Biomedical Research, 2020 Background: Quercetin is the most abundant flavonoid molecule, is widely distributed in the plant kingdom, and has a wide range of uses. Objectives: This study aimed to determine the LD50 of quercetin from onion (Allium cepa) skin (QOS) and its effect ...
Nathan Isaac Dibal +2 more
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Review of the methods to determine the hazard and toxicity of pesticides to bumblebees [PDF]
, 2001 Methods to determine the impact of pesticides on bumblebees are described. They are classified into laboratory tests to determine the acute toxicity and the hazard to bumblebees, (semi) field tests, and brood tests.
Steen, J.J.M., van der +3 more
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Journal of Applied Veterinary Sciences, 2018 The aim of present study was to investigate the phytochemical screening, acute toxicity and some pharmacological activities of ethanolic extract 70 % and 99.9% of apricot seeds.
Ramadan A. +3 more
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