Results 41 to 50 of about 61,903 (248)

LD50 Demo Kit - Danger Adult Solid

, 2021
Glass jar from an LD50 Demo Kit that contains salt to represent a dry formulated pesticide. This jar visually represents an oral LD50 of 50mg/kg for a 160 lb adult, which would have a signal word of Danger/Peligro. This LD50 toxicity level is categorized

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AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

LD50 Demo Kit - Caution Adult/Child Liquid

, 2021
Glass jars from an LD50 Demo Kit that contains red dyed vegetable oil to represent a liquid formulated pesticide. These jars visually represents an oral LD50 of 5000mg/kg for a 160 lb adult (left) and a 55 lb child (right), which would have a signal word

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Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus))

Jurnal Kedokteran Hewan, 2016
The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each.
T. Armansyah TR, Sudi Indriany, Amalia Sutriana, Rosmaidar Rosmaidar, Nuzul Asmilia, Budianto Panjaitan, Dwinna Aliza, Hamdan Hamdan   +7 more
doaj   +1 more source

LD50 Demo Kit - Adult Liquids

, 2020
Glass jars from an LD50 Demo Kit that contains red dyed vegetable oil to represent a liquid formulated pesticide. These jars visually represent oral LD50 quantities for a 160 lb adult.

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LD50 Demo Kit - Caution Adult/Child Solid

, 2021
Glass jars from an LD50 Demo Kit that contain salt to represent a dry formulated pesticide. These jars visually represents an oral LD50 of 5000mg/kg for a 160 lb adult (left) and a 55 lb child (right), which would have a signal word of Caution.

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Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

LD50 Demo Kit - Warning Child Solid

, 2021
Glass jar from an LD50 Demo Kit that contains salt to represent a dry formulated pesticide. This jar visually represents an oral LD50 of 500mg/kg for a 55 lb child, which would have a signal word of Warning/Aviso.

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