Results 231 to 240 of about 839,197 (349)

Artificial intelligence in clinical toxicology in Africa: Emerging applications and barriers. [PDF]

Afr J Emerg Med
Teferi MG, Mengistie BT, Teklehaimanot HK, Mengistie CT, Gemechu FA, Negussie MA, Jufara TJ, Hassen GW.   +7 more
europepmc   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Mechanistic decoding of triclosan-induced endometriosis via network toxicology, Mendelian randomization, and molecular docking. [PDF]

BMC Pharmacol Toxicol
Xu B, Li M, Zhao X, Qin Y, Zhao Y.
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Advancing Dose-Response Research: Integrating Exposome, Multi-Omics, and Low-Dose Phenomena in Toxicology and Medicine. [PDF]

Dose Response
Cai L.
europepmc   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Children's toxicology from bench to bed - Drug-induced Renal Injury (2): Nephrotoxiciy induced by cisplatin and ifosfamide in children

, 2009
Mikiya Fujieda, Akira Matsunaga, Atsushi Hayashi, Hiromichi Tauchi, Kazuaki Chayama, Takashi Sekine   +5 more
openalex   +2 more sources

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source

Intranasal naloxone to treat suspected synthetic cannabinoid overdose: A case report and literature review. [PDF]

Ment Health Clin
Dickinson J, Buckley T.
europepmc   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

Advanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park, Min‐Ji Kim, Jae‐Ho Shin, Eunsoo Kim, Myeongjoo Son, Seungjun Lee   +5 more
wiley   +1 more source