Results 241 to 250 of about 839,197 (349)

Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies. [PDF]

Arch Toxicol
Bearth A, Kopainsky B, Jones LB, Vist GE, Husøy T, Svendsen C, Whaley P, Hoffmann S, Ames HM, Solstad G, Bloch D, Čavoški A, Chiu WA, Davenport M, Davies HG, Giusti A, Hartung T, Kwon S, Osborne OJ, Rooney AA, Rousselle C, Sass JB, Wright FA, Mathisen GH.   +23 more
europepmc   +1 more source

Making Waves: New Developments in Toxicology With the Zebrafish.

Toxicological Sciences, 2018
Katharine A. Horzmann, J. Freeman
semanticscholar   +1 more source

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, EarlyView.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source

Preclinical Toxicological Characterization of Porphyrin-Doped Conjugated Polymer Nanoparticles for Photodynamic Therapy [PDF]

Matías Daniel Caverzán, Ana Belén Morales Vasconsuelo, Laura Cerchia, Rodrigo E. Palacios, Carlos A. Chesta, Luis Exequiel Ibarra   +5 more
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Characteristics and risk factors of opioid poisoning in opioid-dependent individuals using their primary opioid of dependence: a registry-based study. [PDF]

Int J Emerg Med
Nemati A, Etemad L, Dadpour B, Wong A, Gholami M, Mousavi SR, Alizadeh Ghomsari A, Mousavi SH, Ghassemi Toussi A, Kimiafar K, Ataee Z, Vahabzadeh M, Talebpour MA, Arasteh Nodeh AM, Abavisani F, Moshiri M.   +15 more
europepmc   +1 more source

Workshop on manpower development and training in toxicology and chemical safety. Luxembourg, 28 November - 2 December 1983. Industrial health and safety. EUR 9619 EN [PDF]

, 1984
Berlin, A., Smith, E., Tarkowski, S.
core  

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A2 homologue and neutralization by two antivenoms

, 2001
Ermila Rojas, Patricia Saravia, Yamileth Angulo, Viviana Arce, Bruno Lomonte, Juan José Chávez, Rubèn Velàsquez, Monica Thelestam, José Marı́a Gutiérrez   +8 more
openalex   +2 more sources

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source