Results 241 to 250 of about 706,933 (359)

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Nonclinical toxicity study duration in AAV gene therapy development: Evidence from industry survey supports adequacy of short-term assessments. [PDF]

Mol Ther Methods Clin Dev
Assaf BT, Edwards D, Berens SJ, Lauritzen B, Pierrot C, Tukov FF, Bertinetti-Lapatki C, Braun M, Schaefer K, Lynch JL.   +9 more
europepmc   +1 more source

Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding

Advanced Science, EarlyView.
Conventional poly(ethylene glycol) (PEG) is commonly applied in biomedicine, but is now known to induce antibody formation. Here, it is shown that the development of “randomized PEG” (rPEG) featuring glycidyl methyl ether (GME) comonomers decreased antibody binding.
Mareike Deuker, Dominik Schulz, Kaloian Koynov, Svenja Morsbach, Holger Frey, Katharina Landfester   +5 more
wiley   +1 more source

Correction: Dubljević et al. Genotype-Based Housing as a Potential Confounder in Studies Using Transgenic Mouse Models-Insight from the A53T Mouse Model of Parkinson's Disease. <i>Biomedicines</i> 2025, <i>13</i>, 1506. [PDF]

Biomedicines
Dubljević O, Dragoj M, Potrebić Stefanović M, Srbovan M, Stanojlović M, Pavković Ž.   +5 more
europepmc   +1 more source

Toxicological Analysis [PDF]

Journal of Pharmacy and Pharmacology, 1955
openaire   +3 more sources

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

An conscious review validation biodiversity, pharmacognostical, pharmacological, toxicological research studies and therpeautic potential of ASU herbal drugs - seed part of Baphali / Duku / Duqu (Peucedanum grande C.B. Clarke) [PDF]

Pawan Kumar Sagar, S Mageswari, Md Wadud Ahmed   +2 more
openalex   +1 more source

Breaking Down Lignin: A Macromolecule's Path to the Nanoscale

Advanced Energy and Sustainability Research, EarlyView.
This section highlights lignin's critical role as a sustainable, multifunctional precursor for nanomaterial design. Its unique structure and abundance enable the creation of lignin‐based, lignin‐derived, and hybrid nanomaterials with tunable properties. Emphasis is placed on lignin's potential to drive innovation in nanotechnology, offering ecofriendly
Jelena Papan Djaniš, Jan Hočevar, Griša Grigorij Prinčič, Jernej Iskra   +3 more
wiley   +1 more source

Unraveling the mechanisms of nicotine-induced osteoporosis via network toxicology, bioinformatics, and molecular docking. [PDF]

Tob Induc Dis
Xu S, Wang G, Liu J, Zhang X, Dong X, Liang J, Bai T.   +6 more
europepmc   +1 more source