Results 141 to 150 of about 595,436 (374)

PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

Toxins, 2016
The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ±
Nancy Scardua Binda, Charles Porto Petruceli Carayon, Rafael Mourão Agostini, Ana Cristina do Nascimento Pinheiro, Marta Nascimento Cordeiro, Marco Aurélio Romano Silva, Juliana Figueira Silva, Elizete Maria Rita Pereira, Claudio Antonio da Silva Junior, Célio José de Castro Junior, Andre Luiz Sena Guimarães, Marcus Vinicius Gomez   +11 more
doaj   +1 more source

THE SCHICK REACTION AND DIPHTHERIA PROPHYLACTIC IMMUNISATION WITH TOXIN -ANTITOXIN MIXTURE. [PDF]

, 1921
A. T. Glenny, R.A.O. Brien
openalex   +1 more source

Protection against Shiga Toxins

Toxins, 2017
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface.
Simona Kavaliauskiene, Anne Berit Dyve Lingelem, T. Skotland, K. Sandvig   +3 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Shifts of dominant personality and spatial pattern formation due to spatially heterogeneous pollution [PDF]

arXiv
Personality traits, such as boldness and shyness, play a significant role in shaping the survival strategies of animals. Industrial pollution has long posed serious threats to ecosystems and is typically distributed heterogeneously. However, how animals with different personalities respond to spatially heterogeneous pollution remains largely unexplored.
arxiv  

The Separation of Alpha Toxin (Lecithinase) from Filtrates of Clostridium Welchii [PDF]

, 1953
Florence B. Roth, Louis Pillemer
openalex   +1 more source

A 'pain-relieving' toxin [PDF]

Nature Reviews Microbiology, 2014
The Mycobacterium ulcerans toxin mycolactone induces the angiotensin signalling pathway to decrease the sensation of pain from the inflicted lesions.
openaire   +3 more sources

Ancient Venom Systems: A Review on Cnidaria Toxins

Toxins, 2015
Cnidarians are the oldest extant lineage of venomous animals. Despite their simple anatomy, they are capable of subduing or repelling prey and predator species that are far more complex and recently evolved. Utilizing specialized penetrating nematocysts,
M. Jouiaei, A. Yanagihara, B. Madio, T. Nevalainen, P. Alewood, B. Fry   +5 more
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Determination of 16 Hydroxyanthracene Derivatives in Food Supplements Using LC-MS/MS: Method Development and Application

Toxins
Hydroxyanthracene derivatives (HADs) are plant substances produced by a variety of plant species, including different Aloe, Rheum, and Rhamnus species and Cassia senna. These plants are often used in food supplements to improve bowel function.
Svetlana V. Malysheva, Benoît Guillaume, Céline Vanhee, Julien Masquelier   +3 more
doaj   +1 more source