Results 161 to 170 of about 595,436 (374)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
On the power of the liver to destroy diphtheria toxin [PDF]
, 1905 Lauder Brunton, T. J. Bokenham
openalex +1 more source
Toxin yet not toxic: Botulinum toxin in dentistry
The Saudi Dental Journal, 2016 Paracelsus contrasted poisons from nonpoisons, stating that "All things are poisons, and there is nothing that is harmless; the dose alone decides that something is a poison". Living organisms, such as plants, animals, and microorganisms, constitute a huge source of pharmaceutically useful medicines and toxins.
openaire +4 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Bacterial chemotaxis: information processing, thermodynamics, and behavior [PDF]
arXiv, 2015 Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to chemicals, such as nutrients and toxins.
arxiv
Toxicon: XSnake venoms contain various molecules known for activating innate immunity and causing local effects associated with increased vascular permeability, such as vascular leakage and edema, common symptoms seen in snakebite envenomings. We have demonstrated
Emelyn Salazar +6 more
doaj
Die Bindungsgesetze von Toxin und Antitoxin. Von Leonor Michaelis, Privatdozent an der Universität Berlin. 62 Seiten. Verlag von Gebrüder Bornträger, Berlin. 1905. Preis 2 Mk [PDF]
, 1905 Fr. Auerbach
openalex +1 more source
Cryopyrin activates the inflammasome in response to toxins and ATP
Nature, 2006 S. Mariathasan +9 more
semanticscholar +1 more source
Decoy exosomes provide protection against bacterial toxins
Nature, 2020 M. Keller +8 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source