Results 241 to 250 of about 552,298 (312)

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults with Inflammatory Bowel Disease: Data from a Large Administrative Claims Cohort

Arthritis Care &Research, Accepted Article.
Objectives The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in this population, but safety data are mixed. Methods This retrospective cohort study included patients with IBD ≥ 18 years of age from Optum's de‐identified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

The Cardioprotective Potential of Marine Venom and Toxins. [PDF]

Toxins (Basel)
Siagian VHM, Nuwarda RF.
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical applications, challenges, and future directions

Arthritis Care &Research, Accepted Article.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Multispecies Probiotic Supplementation in Chronic Kidney Disease (CKD): Insights From Indian Nephrology Experts. [PDF]

Cureus
Beniwal P, Singla M, Kar DP, Bhargava V, Chandra N, Sinha DK, Ruhela V, Jha R, Joseph R, Rs V, Bhosle N, Mehta K, Bajpai S.   +12 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Large animal models for the assessment of snakebite envenoming therapies. [PDF]

NPJ Drug Discov
Benard-Valle M, Ahmadi S, Modahl CM, Neri-Castro E, Alagón A, Boyer L, Ljungars A, Laustsen AH.   +7 more
europepmc   +1 more source

OnabotulinumToxinA Reduces Pharmacological Burden in Chronic Migraine Patients: A Two-Center Prospective Cohort Study. [PDF]

Toxins (Basel)
Montisano DA, Parisi A, Raggi A, Altamura C, D'Onofrio L, Marcosano M, Fofi L, Marcassoli A, Vernieri F, Grazzi L.   +9 more
europepmc   +1 more source

Chronic Kidney Disease-Associated Defect in Humoral Immune Response Is Driven by Inflammation. [PDF]

Toxins (Basel)
Espi M, Charmetant X, Fusil F, Mathieu C, Legras M, Pelletier C, Glorieux G, Soulage C, Koppe L, Thaunat O.   +9 more
europepmc   +1 more source

Field-Evolved Resistance to Bt Cry Toxins in Lepidopteran Pests: Insights into Multilayered Regulatory Mechanisms and Next-Generation Management Strategies. [PDF]

Toxins (Basel)
Xie J, He W, Qiu M, Lin J, Shu H, Wang J, Liu L.   +6 more
europepmc   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source