Results 81 to 90 of about 113,320 (229)
Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives [PDF]
, 2017 We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties ...
Bizzarri, Bruna +9 more
core +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
Infection and Immunity, 2019 Toxoplasma gondii, a common neurotropic parasite, is increasingly being linked to neuropsychiatric disorders, including schizophrenia, Alzheimer’s disease, and Parkinson’s disease.
Ye Li +4 more
semanticscholar +1 more source
The relation between serum Toxoplasma gondii IgG antibody in children and ADHD and its severity
Psychiatry and Clinical Psychopharmacology, 2019 AIM: The purpose of our study was to investigate the relation between serum Toxoplasma gondii IgG antibodies in children and attention deficit hyperactivity disorder (ADHD) and its severity.
İsmail Akaltun +5 more
doaj +1 more source
eLife, 2020 N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens.
Malgorzata Broncel +13 more
doaj +1 more source
Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility [PDF]
, 2015 Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a type XIV myosin,
Alonso, Hernan +8 more
core +2 more sources
The FEBS Journal, EarlyView.The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source
mBio, 2019 Toxoplasma gondii infects almost all warm-blooded animals, and metabolic flexibility is deemed critical for its successful parasitism in diverse hosts. Glucose and glutamine are the major carbon sources to support parasite growth. In this study, we found
N. Xia +10 more
semanticscholar +1 more source
Biomédica: revista del Instituto Nacional de SaludIntroducción. La toxoplasmosis congénita es una enfermedad parasitaria de importante prevalencia a nivel mundial, con gran morbilidad y afectación del neurodesarrollo en pacientes pediátricos. Objetivo. Describir las secuelas y valorar el neurodesarrollo
Sebastián Posada-Bustos +2 more
doaj +1 more source
Tissue Resident Memory Cells: Friend or Foe?
Immunology, EarlyView.Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude +2 more
wiley +1 more source