Results 61 to 70 of about 66,199 (234)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host

, 2005
The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner.
Henriquez, F L, Muench, S P, Kirisits, M J, Rice, DW, Prigge, ST, Henriquez, FL, Ferguson, DJ, Ferguson, D J P, Rice, D W, Roberts, C W, McLeod, R L, McLeod, RL, Ferguson, David, Kirisits, MJ, Prigge, S T, Muench, SP, Roberts, CW   +16 more
core   +1 more source

Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6 [PDF]

, 2001
A murine model was used to characterize the local immune and inflammatory response during ocular toxoplasmosis. Major histocompatibility complex (MHC) class I, normally expressed at low levels in immune-privileged sites such as the eye, was up-regulated ...
Ferguson, D. J. P., Roberts, C. W., N. Byrne, Anthony, J.P., D. J. P. Ferguson, Lyons, R., R. E. Lyons, Roberts, F., Anthony, J. P., C. W. Roberts, Roberts, C.W., Alexander, J., J. Alexander, Lyons, R. E., Byrne, N., J. P. Anthony, Ferguson, D.J.P., F. Roberts   +17 more
core   +1 more source

Toxoplasmose & Toxoplasma gondii

, 2014
A infecção por Toxoplasma gondii é hoje muito disseminada ao redor do mundo, especialmente no Brasil. A coletânea parte da história da descoberta desse parasita e da doença por ele causada, a toxoplasmose, e visita os diferentes aspectos relacionados ao tema.
Rubens Belfort Jr., Wanderley de Souza
openaire   +2 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages

, 2014
Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins.
Ricardo T. Gazzinelli (164680), Niehus Sebastian, Nahid Azzouz, Debierre-Grockiego Françoise, Schwarz, Ralph T., Sebastian Niehus, Gazzinelli, Ricardo Tostes, Terry K Smith, Schwarz, Ralph T, Debierre-Grockiego, Françoise, Dubremetz , Jean-François, Jean-François Dubremetz, Gazzinelli , Ricardo T, Smith, Terry K., Niehus, Sebastian, Ricardo T Gazzinelli, Ralph T Schwarz, Marco A. Campos (224562), Ricardo T. Gazzinelli, Sebastian Niehus (443448), Gazzinelli, Ricardo T, Marco A Campos, Azzouz Nahid, Ralph T. Schwarz, Campos, Marco Antônio Silva, Gazzinelli Ricardo T., Dubremetz Jean-François, Françoise Debierre-Grockiego (516005), Grockiego, Françoise Debierre, Ralph T. Schwarz (443449), Schwarz Ralph T., Smith Terry K., Marco A. Campos, Terry K. Smith (112550), Campos Marco A., Nahid Azzouz (516004), Campos, Marco A, Smith, Terry K, Dubremetz, Jean-François, Azzouz, Nahid, Françoise Debierre-Grockiego, Dubremetz, Jean François, Terry K. Smith, Jean-François Dubremetz (111711)   +43 more
core   +1 more source

Toxoplasma gondii

, 2020
EXCLI Journal;Vol.
Zaki, Leila, Ghaffarifar, Fatemeh, Sharifi, Zohreh, Horton, John, Sadraei, Javid   +4 more
openaire   +3 more sources

Sero-prevalence of Toxoplasma gondii and associated risk factors among psychiatric outpatients attending University of Gondar Hospital, Northwest Ethiopia

BMC Infectious Diseases, 2019
Background Toxoplasmosis is caused by an obligatory intracellular coccidian protozoan organism, Toxoplasma gondii. It has a worldwide distribution, affecting one-third of the world population.
Barnabas Achaw, Habtie Tesfa, Ayalew Jejaw Zeleke, Ligabaw Worku, Ayenew Addisu, Niguse Yigzaw, Yalewayker Tegegne   +6 more
doaj   +1 more source

Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection. [PDF]

PLoS ONE, 2017
Toxoplasma gondii (T. gondii) microneme protein 8 (MIC8) represents a novel, functional distinct invasion factor. In this study, we generated virus-like particles (VLPs) targeting Toxoplasma gondii MIC8 for the first time, and investigated the protection
Su-Hwa Lee, Ah-Ra Kim, Dong-Hun Lee, Ilaria Rubino, Hyo-Jick Choi, Fu-Shi Quan   +5 more
doaj   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source