Results 171 to 180 of about 149,070 (296)

Prediction of the individual risk for the development of brain metastases in patients with non‐oncogene‐addicted non‐small cell lung cancer: Real‐world data from the German prospective CRISP registry (AIO‐TRK‐0315)

International Journal of Cancer, EarlyView.
What's New? Estimating the risk of developing brain metastases may enable earlier diagnosis and treatment, potentially reducing morbidity and mortality. Using the prospective CRISP lung cancer registry, the authors developed and validated a point‐based classifier for the risk of developing first brain metastases in patients with advanced or metastatic ...
Fabian Acker, Katharina Wenger, Martin Reck, Cornelius F. Waller, Petra Hoffknecht, Andre Bethge, Arnd Nusch, Marcel Reiser, Christiane Bernhardt, Michael Bendel, Carolin Lennartz, Annette Fleitz, Martina Jänicke, Paula Ludwig, Annika Groth, Frank Griesinger, Michael Thomas, Wilfried E. E. Eberhardt, Martin Sebastian, for the CRISP Registry Group   +19 more
wiley   +1 more source

Corrigendum to 'Lazertinib with stereotactic body radiotherapy in oligometastatic EGFR-mutant non-small-cell lung cancer': [ESMO Open. Volume 11, Issue 2, February 2026, 106057]. [PDF]

ESMO Open
Lee JB, Kim KH, Yoon S, Song SY, Lee SS, Jo S, Ahn HK, Kim HJ, Choi SJ, Park H, Hong MH, Cho BC, Yoon HI, Lim SM.   +13 more
europepmc   +1 more source

Long-term analysis of the RiBVD phase II trial reveals the unfavorable impact of <i>TP53</i> mutations and hypoalbuminemia in older adults with mantle cell lymphoma; for the LYSA group.

, 2023
Sylvain Carras, Alexia Torroja, Anouk Emadali, Émilie Montaut, Nicolas Daguindau, Adrian Tempescul, Philippe Moreau, Emmanuelle Tchernonog, Anna Schmitt, Roch Houot, Caroline Dartigeas, Sarah Barbieux, Sélim Corm, Anne Banos, Ludovic Fouillet, Jehan Dupuis, Margaret Macro, Joël Fleury, Fabrice Jardin, Clémentine Sarkozy, G. Damaj, Pierre Feugier, Luc Matthieu Fornecker, Cécile Moluçon‐Chabrot, Véronique Dorvaux, Krimo Bouabdallah, Sandy Amorim, Réda Garidi, Laurent Voillat, Bertrand Joly, Nadine Morineau, Marie Pierre Moles, Hacène Zerazhi, Jean Fontan, Yazid Arkam, Magda Alexis, Vincent Delwail, Jean Pierre Vilque, Loïc Ysebaert, Barbara Burroni, Mary Callanan, Steven Le Gouill, Rémy Gressin   +42 more
openalex   +2 more sources

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

A proposal for expedited stem cell transplantation for TP53-mutant myelodysplastic neoplasms and acute myeloid leukemia. [PDF]

Blood Adv
Patel SA, Devine SM, Cerny J.
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients

, 2018
Guoli Li, Xinwu Guo, Ming Chen, Lili Tang, Hui Jiang, Julia X. Day, Yueliang Xie, Limin Peng, Xunxun Xu, Jinliang Li, Shouman Wang, Zhi Xiao, Lizhong Dai, Jun Wang   +13 more
openalex   +2 more sources

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

Identification of two novel TP53 mutations in secondary acute myeloid leukemia following multiple myeloma: a case report. [PDF]

Blood Sci
De Francesco MA, Ribolla R, Sottini A, Bertoli D, Giupponi C, Bonuccelli O, Bresciani R, Tucci A, Biasiotto G.   +8 more
europepmc   +1 more source