Results 51 to 60 of about 29,050 (250)

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

Biomaterials Research, 2023
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery
Huifang Wang, Runhua Zhou, Fushan Xu, Kongjun Yang, Liuhai Zheng, Pan Zhao, Guangwei Shi, Lingyun Dai, Chengchao Xu, Le Yu, Zhijie Li, Jianhong Wang, Jigang Wang   +12 more
doaj   +1 more source

Thermally Assisted Photocatalytic Dehydrogenation of Methanol in Continuous Steady‐State Operation

Advanced Science, EarlyView.
Thermally assisted photocatalytic methanol dehydrogenation on Pt/TiO2 enables formaldehyde and hydrogen production far beyond thermodynamic limits. Continuous operation delivers up to 95% selectivity over 70 h, and oxygen microdosing strongly boosts conversion by regenerating surface oxygen sites.
Florian Stubenrauch, Phillip Nathrath, Markus Schörner, Yazan Mahayni, Birk Fritsch, Andreas Hutzler, Peter Wasserscheid, Andreas Bösmann, Patrick Schühle   +8 more
wiley   +1 more source

Preparation and characterization of Mg-modified zirconias as catalysts for the direct synthesis of dimethyl carbonate (DMC)

Revista Facultad de Ingeniería Universidad de Antioquia, 2011
Se preparó circonia por el método sol-gel usando H2SO4, HNO3 o HCl como catalizadores de hidrólisis. Los materiales resultantes se caracterizaron por DRX, BET, FTIR, desorción de CO2 con temperatura programada (TPDCO 2) y desorción de amoníaco con ...
Andrés Orrego Romero, Consuelo Montes de Correa, Felipe Bustamante Lodoño   +2 more
doaj  

A personalized learning system-supported professional training model for teachers' TPACK development

Computers and Education: Artificial Intelligence, 2022
In contrast to traditional teacher professional development (TPD), the importance of individualized professional learning and expert content delivery is increasingly focused on as a challenge to transform the TPD.
Pawat Chaipidech, Niwat Srisawasdi, Tanachai Kajornmanee, Kornchawal Chaipah   +3 more
doaj   +1 more source

TPD @scale compendium

, 2023
This Compendium is a knowledge product resulting from the activities of the TPD@Scale Coalition for the Global South. It offers examples of large-scale or potentially scalable information and communications technology (ICT)-mediated teacher professional ...
Wolfenden, Freda, Boateng, Pearl
core  

Spectral‐Kinetic Synergy in Au‐Network Engineered FeTiO3: A Multi‐Field Coupling Strategy for Lunar In Situ Resource Utilization

Advanced Science, EarlyView.
How can humanity achieve lunar self‐sufficiency? We utilize Au topology networks to modify the abundant lunar ilmenite. This catalyst, under sunlight, can convert waste carbon dioxide into space fuel. This design leverages the moon's natural vacuum for green manufacturing, avoiding the waste of gold and serving as “artificial chloroplasts” to sustain ...
Yahang Wang, Quanxin Wang, Pakkin Leong, Shi Feng, Meng Wang, Runyang Mo, Xianjin Shi, Xiaohui Li, Gangqiang Zhu, Chipui Tang   +9 more
wiley   +1 more source

Targeted protein degradation in cancers: Orthodox PROTACs and beyond

The Innovation, 2023
Targeted protein degradation (TPD) is emerging as a strategy to overcome the limitations of traditional small-molecule inhibitors. Proteolysis-targeting chimera (PROTAC) technology can be used to target proteins by hijacking the ubiquitin-proteasome ...
Jin Li, Xinxin Chen, Aiping Lu, Chao Liang   +3 more
doaj   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Subtle side chain modification of triphenylamine‐based polymer hole‐transport layer materials produces efficient and stable inverted perovskite solar cells

Interdisciplinary Materials, 2022
Polymer hole‐transport layers (HTLs) are critical components of inverted perovskite solar cells (IPVSCs). Triphenylamine derivatives PTAA (poly[bis(4‐phenyl)(2,4,6‐trimethylphenyl)amine]) and Poly‐TPD (poly[N,N′‐bis(4‐butylphenyl)‐N,N′‐bis(phenyl ...
Yue‐Min Xie, Qin Yao, Qifan Xue, Zixin Zeng, Tianqi Niu, Yingzhi Zhou, Ming‐Peng Zhuo, Sai‐Wing Tsang, Hin‐Lap Yip, Yong Cao   +9 more
doaj   +1 more source

High‐Entropy Engineering and External Magnetic Field Modulation Synergistically Enhance the H2S Sensing Performance of Rare‐Earth Perovskite Ferrites

Advanced Science, EarlyView.
A novel high‐entropy perovskite oxide, (Gd0.2Tb0.2Dy0.2Ho0.2Er0.2)FeO3, was successfully synthesized for advanced hydrogen sulfide gas detection. By synergistically coupling high‐entropy‐induced local lattice distortion with weak magnetic field modulation, the tailored material generates abundant active sites. This innovative dual strategy dramatically
Yunfei Wang, Min Zhang, Rui Li, Xiaolong Yao, Zhaofeng Wu, Fengdong Qu, Shan Qiu, Zhenjiang Li   +7 more
wiley   +1 more source