Results 201 to 210 of about 80,997 (253)

Treatment patterns, strategies, and preferences after first anti‐seizure medication failure in focal epilepsy: Findings from the SANAD and SANAD II trial cohorts and a survey of UK epilepsy specialists

open access: yesEpilepsia, EarlyView.
Abstract Objective To describe treatment decisions after first anti‐seizure medication (ASM) failure in focal epilepsy and describe how they have changed across two trial eras, and whether observed prescribing matched clinicians stated preferences. Methods We analyzed the focal epilepsy cohorts from two UK pragmatic, randomized trials, Standard and New
Isaac J. Egesa   +4 more
wiley   +1 more source

Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA‐epilepsy study

open access: yesEpilepsia Open, EarlyView.
Abstract Objectives Temporal lobe epilepsy (TLE) impacts multiple brain networks. Aberrant functional connectivity has been demonstrated in resting‐state networks (RSNs) that mediate higher brain functions in TLE. This study aimed to identify the reproducible patterns of altered functional connectivity in TLE in a large, international cohort through ...
Victoria Ives‐Deliperi   +28 more
wiley   +1 more source

Efficacy of stiripentol, fenfluramine, and their combination on clinical outcomes in Dravet syndrome: A preliminary report

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Stiripentol and fenfluramine are approved treatments for Dravet syndrome (DS), but real‐world data comparing their effectiveness and combined use remain limited. Our study aims to explore associations between treatment with stiripentol, fenfluramine, and their combination and clinical outcomes in patients with DS.
Paolo Surdi   +7 more
wiley   +1 more source

Preliminary evidence of long‐term safety and effectiveness of anti‐CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

open access: yesEpilepsia Open, EarlyView.
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Marina Romozzi   +13 more
wiley   +1 more source

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