Results 1 to 10 of about 36,003 (284)

Lacosamide versus topiramate in episodic migraine: a randomized controlled double-blinded trial [PDF]

Therapeutic Advances in Neurological Disorders
Background: Although migraine is the second most prevalent form of headache, its preventive treatment has some contraindications and complications. It has been postulated that lacosamide reacts with collapsin response mediator protein 2 and prevents its ...
Mohamed G. Zeinhom, Mohamed Fouad Elsayed Khalil, Mohamed Almoataz, Tarek Youssif Omar Youssif, Ahmed Mohamed Ali Daabis, Hossam Mohamed Refat, Ahmed Ahmed Mohamed Kamal Ebied, Shady S. Georgy, Ahmed Zaki Omar Akl, Mohamed Ismaiel, Salah Ibrahim Ahmed, Hesham Farouk Eissa, Asmaa Ibrahem Desouky Mostafa Ibrahem, Asmaa Mohammed Hassan, Mohamed Elshafei, Amir Ahmed Elsaeed Egila, Sherihan Rezk Ahmed   +16 more
doaj   +2 more sources

Risk of neurodevelopmental disorders after fetal topiramate exposure: a systematic review [PDF]

Frontiers in Drug Safety and Regulation
IntroductionRecent studies suggest an association between fetal topiramate exposure and an increased risk of neurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD), intellectual disability (ID) and attention deficit hyperkinetic ...
Renate Eikevåg Lundøy, Anniken Sigvathsen, Marte-Helene Bjørk, Marte-Helene Bjørk, Nils Erik Gilhus, Nils Erik Gilhus, Jenny Linnea Victoria Lindroos, Jenny Linnea Victoria Lindroos   +7 more
doaj   +2 more sources

Topiramate augmentation in refractory obsessive-compulsive disorder: A randomized, double-blind, placebo-controlled trial [PDF]

Journal of Research in Medical Sciences, 2014
Background: This study aimed to assess the efficacy of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (OCD) as an adjunct to serotonin reuptake inhibitors (SRIs). Materials and Methods: Thirty-
Hamid Afshar, Shahla Akuchekian, Behzad Mahaky, Elham Zarean   +3 more
doaj   +4 more sources

A new method for the preparation of pure topiramate with a micron particle size [PDF]

Journal of Particle Science and Technology, 2017
Crude topiramate was prepared from the reaction between diacetonefructopyranose, sulfuric diamide, and 2-picoline. During a controlled processing the presence of Triton-X-100, crude topiramate in a methanol-water solvent, was converted to pure micron ...
Bahman Hassanzadeh, Farajollah Mohanazadeh   +1 more
doaj   +1 more source

Influence of Tiapride and Topiramate on Tic Severity and Behavioral/Emotional Problems in Children with Tourette Syndrome: A Retrospective Study

Brain Sciences, 2023
Objectives: To investigate the effect of tiapride and topiramate on patients with Tourette syndrome (TS). Methods: This retrospective analysis included 126 children diagnosed with TS at Children’s Hospital of Chongqing Medical University from 2019 to ...
Xuanzi Zhou, Zhaoying Liao, Yi Li, Nanqing Wang, Nong Xiao   +4 more
doaj   +1 more source

Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Acta Crystallographica Section E: Crystallographic Communications, 2022
The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructopyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug ...
Prabhakar Priyanka, Bidarur K. Jayanna, Haruvegowda Kiran Kumar, Vinaya, Thayamma R. Divakara, Hemmige S. Yathirajan, Christopher Glidewell, Sean Parkin   +7 more
doaj   +1 more source

Topiramate induced bilateral hypopyon uveitis and choroidal detachment: a report of two cases and review of literature

BMC Ophthalmology, 2021
Background Topiramate (TPM) is a drug commonly used by neurophysicians and psychiatrists for a plethora of indications. Topiramate has been reported to induce acute angle closure glaucoma as an adverse effect.
Mudit Tyagi, Shashwat Behera, Sirisha Senthil, Rajeev R. Pappuru, Vikas Ambiya, Siddharth Dikshit   +5 more
doaj   +1 more source

Topiramate intoxications & hemodialysis – Literature review and the first case report of a massive suicidal intoxication treated with hemodialysis

Toxicology Reports, 2022
Background: Topiramate is an anticonvulsant from sulfamate-substituted monosaccharides that is increasingly used to treat migraines. Serious topiramate intoxications have been described.
Tim Schutte, Anne van Tellingen, Janneke van den Broek, Marloes ten Brink, Marleen G. van Agtmael-Boerrigter   +4 more
doaj   +1 more source

Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

Pharmaceuticals, 2023
Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ...
Hany H. Arab, Ahmed H. Eid, Rania Yahia, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Marwa A. Masoud   +9 more
doaj   +1 more source

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. [PDF]

, 2021
Objectives/hypothesisTo examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment.
Abouzari, Mehdi, Chua, Janice T, Djalilian, Hamid R, Goshtasbi, Khodayar, Lin, Harrison W, Saber, Tina, Sarna, Brooke, Tan, Donald   +7 more
core   +1 more source