Results 31 to 40 of about 28,018 (262)

Topiramate: Safety and Efficacy of its Use in the Prevention and Treatment of Migraine [PDF]

, 2011
Migraine headaches are typically episodic in nature and may affect nearly 10% of the population. In addition to treatment, prevention of subsequent episodes or progression to a chronic migraine state is an important therapeutic area.
April D. Miller, Ginger C. Minton, Minton, Ginger C, P. Brandon Bookstaver, Bryan L. Love, Bookstaver, P Brandon, Miller, April D, Love, Bryan L   +7 more
core   +1 more source

Chemical structural of topiramate.

, 2022
Chemical structural of topiramate.
Yuan Zeng (332785), Hui Liu (33624), Qiongzhi Shi (12152765), Xiangyang Xie (220273), Wen Lin (36325), Xiangru Liao (2047639), Wei Tian (291921), Yinke Li (6728489)   +7 more
core   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Topiramate for Abnormal Eating Behaviour in Frontotemporal Dementia [PDF]

, 2013
Topiramate is a sulfamate-substituted monosaccharide anticonvulsant that is associated with anorexia and weight loss and has been used to treat binge eating disorder and bulimia nervosa.
Velakoulis, D, Singam, C, Evans, A, Mocellin, R, Ramon Mocellin, Andrew Evans, Walterfang, M, Mark Walterfang, Colin Singam, Dennis Velakoulis   +9 more
core   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Topiramate-induced Myopic Shift and Bilateral Secondary Angle-closure Glaucoma

, 2012
In this case report, we discuss a 24-year-old female patient with diagnosis of epilepsy who developed myopia and acute bilateral angleclosure glaucoma after 7 days of treatment with topiramate.
Hatice Tarakçıoğlu, Ulviye Yiğit, Özgür Örüm   +2 more
core   +1 more source

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Iatrogenic topiramate poisoning in an ICU patient: Focus on topiramate peak time prolongation [PDF]

, 2021
A 35-year-old man with generalized insults was admitted to the intensive care unit because of third-line treatment of persistent epileptic insults with antiepileptic drug therapy.
le Noble, J.L.M.L., Janssen, P.K.C.; id_orcid, Hoebregts, V.M.G., Foudraine, N., Paddy K.C. Janssen, Norbert Foudraine, Jos L.M.L. le Noble, Vera M.G. Hoebregts   +7 more
core   +1 more source

Topiramate on the quality of life in childhood epilepsy.

, 2011
This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664
김흥동, Heung-Dong Kim, Eom, SY, Korean Pediatric Topiramate Study Group, So-Yong Eom, Da-Eun Jung, Hur, YJ, Yun-Jung Hur, Kim, HD, Jung, DE   +9 more
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source