Results 41 to 50 of about 36,003 (284)

Topiramate and Pregabalin in Lumbar Radicular Pain. Is Topiramate a better option?

Journal of Rawalpindi Medical College, 2020
Objective: To compare the efficacy of two anticonvulsant drugs topiramate and pregabalin on lumbar radicular pain and to find out whether topiramate is a better option or not. Study design: Experimental study.
Asim Ishfaq, Javaria Ashraf, Aimen Haider   +2 more
doaj   +1 more source

Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders [PDF]

, 2019
Objective To systematically evaluate the efficacy of treatments for tics and the risks associated with their use. Methods This project followed the methodologies outlined in the 2011 edition of the American Academy of Neurology\u27s guideline development
Cavanna, Andrea E, Holler-Managan, Yolanda, Jankovic, Joseph, Jarvie, Elizabeth, Martino, Davide, Müller-Vahl, Kirsten, Okun, Michael S, Oskoui, Maryam, Piacentini, John, Pringsheim, Tamara, Robinson, Michael, Roessner, Veit, Woods, Douglas W   +12 more
core   +2 more sources

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

A review of the efficacy and safety of extended-release topiramate in the adjunctive treatment for refractory partial-onset seizures

Therapeutic Advances in Neurological Disorders, 2015
Topiramate has been widely utilized worldwide as an effective medication against partial- and generalized-onset seizures. Extended-release topiramate was developed to provide patients with the convenience of once-daily dosing and potentially improved ...
Steve S. Chung
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Topiramate alters the gut microbiome to aid in its anti-seizure effect

Frontiers in Microbiology, 2023
IntroductionThere is a growing interest in the role of the gut microbiota in epilepsy, however, it is unclear if anti-seizure medications (ASMs) play a role in the gut-brain axis.
K'Ehleyr Thai, K'Ehleyr Thai, Michael W. Taylor, Tatiane Fernandes, Eunice A. Akinade, Susan L. Campbell, Susan L. Campbell   +6 more
doaj   +1 more source

A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish. [PDF]

, 2016
Zebrafish are a popular vertebrate model for human neurological disorders and drug discovery. Although fecundity, breeding convenience, genetic homology and optical transparency have been key advantages, laborious and invasive procedures are required for
Baraban, Scott C, Hong, SoonGweon, Lee, Luke P, Lee, Philip   +3 more
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Erenumab versus topiramate: post hoc efficacy analysis from the HER-MES study

The Journal of Headache and Pain, 2022
Objective HER-MES was the first head-to-head, phase 4 trial to assess the tolerability and effectiveness of erenumab against standard of care treatment (topiramate). This post hoc analysis compared the efficacy of erenumab with topiramate in patients who
Marc Ehrlich, Christian Hentschke, Christian Sieder, Monika Maier-Peuschel, Uwe Reuter   +4 more
doaj   +1 more source

Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. [PDF]

, 2013
Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of ...
Mula, M
core   +3 more sources