Results 101 to 110 of about 13,348 (285)
Advanced Science, EarlyView.The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia +15 more
wiley +1 more source
Advanced Science, EarlyView.Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu +12 more
wiley +1 more source
Virtual and Physical PrototypingTo address the limitations of traditional acoustic materials characterised by ‘high absorption but low load-bearing capacity, and high load-bearing but poor absorption,’ this study focuses on developing a multifunctional integrated structure that ...
Peng-Fei Zhang +12 more
doaj +1 more source
Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean
Advanced Science, EarlyView.This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma +11 more
wiley +1 more source
Advanced Science, EarlyView.BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng +8 more
wiley +1 more source
Journal of Low Frequency Noise, Vibration and Active ControlPoly(methyl methacrylate)-based triply periodic minimal surfaces (TPMS) structures promise great potential in phononic applications, but the complicated TPMS structure induces a design challenge for controlling their properties.
Jin-You Lu +4 more
doaj +1 more source
Advanced Science, EarlyView.A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng +16 more
wiley +1 more source
SoftwareXMaSMaker 2.0 aims to contribute to the computational design and fabrication of Triply Periodic Minimal Surface (TPMS) structures. This updated version expands the capabilities of the software in three aspects: (1) the repertoire of available TPMS ...
James Pérez-Barrera +5 more
doaj +1 more source
Management issues in systems engineering [PDF]
When applied to a system, the doctrine of successive refinement is a divide-and-conquer strategy. Complex systems are sucessively divided into pieces that are less complex, until they are simple enough to be conquered.
Aster, Robert +7 more
core +1 more source
Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
wiley +1 more source