Results 101 to 110 of about 8,384 (285)

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Multi-objective topology optimization and numerical investigation of heat sinks based on triply periodic minimal surface lattices

Case Studies in Thermal Engineering
In thermal management applications, such as heat sinks (HSs) for electronic devices, cellular materials have extensively been employed. In recent years, there has been a growing attention towards employing topology optimization for enhancing hydraulic ...
Mohamad Modrek, Kamran A. Khan, Mohamed I.Hassan Ali, Rashid K. Abu Al-Rub   +3 more
doaj   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Spatially distributed and interconnected porous architectures for dental implants

International Journal of Implant Dentistry
Purpose Patients with pre-existing medical conditions that impair bone integrity face challenges in dental implant success due to compromised osseointegration. This study evaluates three titanium interconnected porous architectures: the TPMS solid gyroid,
Rana Dabaja, W. Benton Swanson, Sun-Yung Bak, Gustavo Mendonca, Yuji Mishina, Mihaela Banu   +5 more
doaj   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Acoustics-mechanics synergistic sheet Diamond-TPMS/polyimide interpenetrating composite structure: broadband sound absorption and high load-bearing characteristics

Virtual and Physical Prototyping
To address the limitations of traditional acoustic materials characterised by ‘high absorption but low load-bearing capacity, and high load-bearing but poor absorption,’ this study focuses on developing a multifunctional integrated structure that ...
Peng-Fei Zhang, Zhong-Hua Li, Yu-Jun Zhou, Ke Shi, Qi-Fei Zhang, Bo-Tao Yan, Miao Zhao, Yin-Zhuo Li, Fei Liu, Bin Liu, Pei-Kang Bai, Hong-Wen Li, Wen-Juan Huo   +12 more
doaj   +1 more source

Fatigue analysis of TPMS structures [PDF]

V magistrski nalogi je predstavljena numerična študija določevanja življenjske dobe izbranih TPMS struktur. V začetnem delu je predstavljeno teoretično ozadje določevanja življenjske dobe, osnove celičnih struktur in njihovo mehansko obnašanje.
Rikić, Aleksej
core  

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Effect of Unit Cell Topology on Dielectric Properties of Periodic Lattice Materials Used for Functionally Graded Insulation

High Voltage
Periodic lattice material (PLM) is an innovative material system capable of rapidly and efficiently constructing functionally graded materials (FGMs).
Zihao Liu, Wendong Li, Peng Sun, Ni Wang, Xin Zhao, Yucheng Zhang, Chao Wang, Guanjun Zhang   +7 more
doaj   +1 more source

3D printing of thermoplastic polyurethane TPMS structures via selective laser sintering

, 2022
According to American Society for Testing and Materials (ASTM), additive manufacturing (AM) is defined as “a process of joining materials to make objects from 3D model data, usually layer upon layer, as opposed to subtractive manufacturing methodologies”.
Lee, Jia Shin
core