Results 111 to 120 of about 18,195 (319)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Insights into acoustic properties of seven selected triply periodic minimal surfaces-based structures: A numerical study

Journal of Low Frequency Noise, Vibration and Active Control
Poly(methyl methacrylate)-based triply periodic minimal surfaces (TPMS) structures promise great potential in phononic applications, but the complicated TPMS structure induces a design challenge for controlling their properties.
Jin-You Lu, Tarcisio Silva, Fatima Alzaabi, Rashid K Abu Al-Rub, Dong-Wook Lee   +4 more
doaj   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Dynamic response-based isogeometric analysis of graphene platelets-reinforced functionally graded triply periodic minimal surface plates supported by Pasternak foundation

Alexandria Engineering Journal
Recent progress in additive manufacturing (AM) has transformed how complex bioinspired engineering structures are designed and produced. Nonetheless, these structures present substantial difficulties in mathematical modeling and computational analysis ...
Ngoc-Tu Do, Huu Trong Dang, Trung Thanh Tran, Nguyen Vinh Du, Quoc Hoa Pham   +4 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

Compressive Characteristics and Energy Absorption Capacity of Automobile Energy-Absorbing Box with Filled Porous TPMS Structures

Applied Sciences
In order to meet the higher requirements of energy-absorbing structures in the lightweight automobile design, the mechanical design and impact energy absorption of porous TPMS structures are studied. Eight kinds of porous TPMS structure elements, Gyroid,
Xuejin Zhao, Zhenzong Li, Yupeng Zou, Xiaoyu Zhao   +3 more
doaj   +1 more source

ctOS-TPMS

, 2021
Hoy en día los elementos de seguridad de los vehículos se han convertido en una pieza clave a la hora de evitar accidentes y de reducir las posibles lesiones que estos puedan producir. De entre todos los sistemas de seguridad existentes, este proyecto se enfoca en el TPMS, el sistema de monitorización de presión de los neumáticos obligatorio desde 2014
María Martín, Jorge, Rodríguez Fuentes, Alberto, García Fuentes, Martín   +2 more
openaire   +1 more source

The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein‐E deficient mice [PDF]

, 2017
Roksan Libinaki, Antony Vinh, Sonja Tesanovic‐Klajic, Robert E. Widdop, Tracey A. Gaspari   +4 more
openalex   +1 more source