Results 61 to 70 of about 33,600 (316)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The relationship between copyright and contract law [PDF]

, 2010
Contracts lie at the heart of the regulatory system governing the creation and dissemination of cultural products in two respects: (1) The exclusive rights provided by copyright law only turn into financial reward, and thus incentives to creators ...
Derclaye, Estelle, Favale, Marcella, Kretschmer, Martin, Watt, Richard   +3 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A turning point analysis of the ergodic dynamics of iterative maps

, 1997
The dynamics of one dimensional iterative maps in the regime of fully developed chaos is studied in detail. Motivated by the observation of dynamical structures around the unstable fixed point we introduce the geometrical concept of a turning point which
Diakonos, F. K., Schmelcher, P.
core   +1 more source

Different coordination modes of an aryl-substituted hydrotris(pyrazolyl) borate ligand in rhodium and iridium complexes [PDF]

, 2011
Complexes TptolRh(C2H4)2 (1a) and TptolRh(CH2C(Me)C(Me)CH2) (1b) have been prepared by reaction of KTptol with the appropriate [RhCl(olefin)2]2 dimer (Tptol means hydrotris(3-p-tolylpyrazol-1-yl)borate).
Carmona Guzmán, Ernesto, Conejero Iglesias, Salvador, Esqueda Oliva, Ana Cristina, Maya Díaz, Celia María, Valpuesta, José Enrique V., Álvarez González, Eleuterio   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Energy absorption of gradient triply periodic minimal surface structure manufactured by stereolithography

Reviews on Advanced Materials Science
Triply periodic minimal surface (TPMS) metamaterials possess exceptional properties not commonly found in natural materials. TPMS metamaterials are used in lightweight structures and impact energy absorption structures due to their surface geometry and ...
Liang Yingjing, He Huiyi, Yin Jun, Liu Yijie, Huang Jianzhang, Wu Zhigang, Zhai Yun, Hui David, Yan Lewei   +8 more
doaj   +1 more source

Bending behavior of additively manufactured short fiber reinforced composite sandwich structures based on triply periodic minimal surface

Polymer Testing
Triply periodic minimal surfaces (TPMSs) have gained increasing attention because of their excellent mechanical properties and scalability. The Gyroid TPMS core sandwich (G-TPMS sandwich) structure was designed, and its bending performance and failure ...
Yaozhong Wu, Xuepeng Li, Shaoan Li, HuaWei Wang, Peng Wang, Weijia Li   +5 more
doaj   +1 more source

The period of a classical oscillator

, 2004
We develop a simple method to obtain approximate analytical expressions for the period of a particle moving in a given potential. The method is inspired to the Linear Delta Expansion (LDE) and it is applied to a large class of potentials.
Amore P., Amore P., Amore P., Bender C. M., Drazin P. G., P Amore, R. A Sáenz, Weinberg S.   +7 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source