Results 91 to 100 of about 120,185 (299)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló   +5 more
wiley   +1 more source

Patient Attitudes Toward Testicular Prosthesis Placement After Orchiectomy

open access: yesAmerican Journal of Men's Health, 2019
Orchiectomy is the standard of care for many testicular conditions. Testicular prosthesis placement (TPP) can mitigate psychosocial burden, restore self-image, and improve quality of life for patients requiring orchiectomy.
Ashwin Srivatsav   +7 more
doaj   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet   +17 more
wiley   +1 more source

The International Trade Commission's Assessment of the Trans-Pacific Partnership: Main Findings and Implications [PDF]

open access: yes, 2016
In May of 2016 the United States International Trade Commission (ITC) issued its assessment of the impact of the Trans-Pacific Partnership (TPP). This paper highlights the main findings of the ITC report and explains their derivation and implications. It
Dean Baker
core  

Role of oxygen-oxygen hopping in the three-band copper-oxide model: quasiparticle weight, metal insulator and magnetic phase boundaries, gap values and optical conductivity

open access: yes, 2011
We investigate the effect of oxygen-oxygen hopping on the three-band copper-oxide model relevant to high-$T_c$ cuprates, finding that the physics is changed only slightly as the oxygen-oxygen hopping is varied.
A. J. Millis   +3 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

open access: yesBMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang   +12 more
wiley   +1 more source

KEEFEKTIFAN STRATEGI VISUAL DALAM PEMBELAJARAN KETERAMPILAN SOSIAL PADA ANAK DENGAN KONDISI SPEKTRUM AUTIS TIPE SINDROMA ASPERGER (ASD)

open access: yesJurnal Kesehatan, 2016
Kefektifan Strategi Visual dalam Pembelajaran Keterampilan Sosial pada Anak dengan Kondisi Spektrum Autis Tipe Sindroma Asperger (ASD). Perilaku tantrum merupakan perilaku yang sering muncul pada anak spektrum autisme, berupa perilaku  mengamuk, amarah ...
Wawan Wawan, Anna Anna
doaj   +1 more source

A Prisoners\u27 Island: Teaching Australian Incarcerated Students in the Digital Age [PDF]

open access: yes, 2014
While incarcerated students have always faced many obstacles to full and effective participation in university study, the global shift toward paperless e-learning environments has created new challenges for prisoners without direct internet access. Based
Farley, Helen, Hopkins, Susan
core   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

open access: yesBMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma   +9 more
wiley   +1 more source

The Comprehensive and Progressive Trans-Pacific Partnership Policy Innovations and Impacts. Bertelsmann GED Focus Paper [PDF]

open access: yes, 2018
Why did the member states in what eventually became the Comprehensive and Progressive Trans-Pacific Partnership (CPTPP) agree to create the most transformational free trade agreement (FTA) in decades?
Elms, Deborah
core  

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