Results 171 to 180 of about 52,541 (305)

Cross‐Platform Comparison of Chemoproteomics Workflows: Orbitrap‐TMT Versus timsTOF‐diaPASEF

PROTEOMICS, EarlyView.
ABSTRACT Chemoproteomics aims to achieve precise and comprehensive quantification of protein–small molecule interactions, yet methodological comparisons across quantitative proteomics workflows remain scarce. Here, we systematically benchmark tandem mass tag data‐dependent acquisition (TMT‐DDA) on Orbitrap Exploris/Eclipse instruments against label ...
Ursula M. Glocker, Michael Steidel, Henrik Hammarén, Carola Doce, Katrin Marcus, Nico Zinn, Marcus Bantscheff, H. Christian Eberl   +7 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Porphyrin-based metallo-organic cage for selective photocatalysis under heterogeneous and atmospheric conditions. [PDF]

Chem Sci
Bai Q, Chen G, Wu T, Zhang W, Chen H, Li T, Li X, Guan YM, Chen Z, Wang M, Wang P, Zhang Z.   +11 more
europepmc   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Characterizing Age Effects on Wideband Absorbance in Normal-Hearing Children Via Statistical and Machine Learning Analyses. [PDF]

J Otol
Qiu J, Shen C, Wang Y, Lai X, Mu Y, Zhao F, Liu W, Jiang W.   +7 more
europepmc   +1 more source

Responsive nanoheterojunctions for built‐in electric field‐promoted cascade tumor targeting and cuproptosis‐based therapy

Responsive Materials, EarlyView.
Nanoheterojunctions have been synthesized as responsive biomaterials for cascade targeting of tumor cells and mitochondria, ROS‐mediated apoptosis and Cu‐promoted cuproptosis. And drug‐device‐field integration as an advanced paradigm of tumor treatment was employed for photo‐triggered tumor cell elimination in vitro and lesion eradication in vivo ...
Zhe Liu, Yandai Lin, Xuehui Li, Fengqi Xuan   +3 more
wiley   +1 more source

In situ sol-gel-sol transformation formed by sodium alginate realizes folic acid-modified chitosan nanoparticles to deliver hops β-acids for colorectal cancer therapy. [PDF]

J Nanobiotechnology
Qiao X, Liu J, Bai J, Xu C, Zhao Q, Guo S, Ding L, Ma D, Zhang X, Tian B.   +9 more
europepmc   +1 more source

Covalent Functionalization of NiFe Layered Double Hydroxides using Tris(Hydroxymethyl)Aminomethane

Small, EarlyView.
Covalent functionalization of NiFe layered double hydroxides with tris(hydroxymethyl)aminomethane enables controlled growth, enhanced structural order, and improved processability. Temporary TRIS anchoring promotes stable water‐based inks and binder‐free electrode fabrication, leading to enhanced oxygen evolution activity and long‐term stability under ...
Alvaro Seijas Da Silva, Federico Juarez‐Dominguez, Víctor Oestreicher, Martín Mizrahi, Diego Hunt, Bruno J. C. Vieira, Joao C. Waerenborgh, Valeria Ferrari, Gonzalo Abellán   +8 more
wiley   +1 more source

Heavy‐Metal‐Free Colloidal Quantum Dots for Photocatalysis

Small, EarlyView.
Heavy‐metal‐free colloidal quantum dots provide sustainable photocatalytic platforms by combining tunable band structures, strong light absorption, and programmable surfaces/interfaces. This Review highlights how core/shell engineering, alloying, defect regulation, ligand design, and hybrid‐interface construction direct charge separation and ...
Xintong Xu, Ge Yang, Qin Li, Dechao Chen
wiley   +1 more source

Thyrotoxic Periodic Paralysis Following a 75-g Oral Glucose Load Revealing Previously Undiagnosed Graves' Disease: A Case Report. [PDF]

Clin Med Insights Case Rep
Verma A, Sudan S, Singla M, Suvvari TK, Ronald T, Kumar S.   +5 more
europepmc   +1 more source