Results 11 to 20 of about 162,834 (322)

The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Nature Communications, 2021
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani   +21 more
doaj   +2 more sources

Thermoplastic Rubber (TPR) Modified by a Silane Coupling Agent and Its Influence on the Mechanical Properties of Oil Well Cement Pastes

Advances in Materials Science and Engineering, 2019
The surface hydrophilicity of thermoplastic rubber (TPR) is poor, and the effect of using it directly in oil well cement is not good. TPR was modified by different silane coupling agents, and the hydrophilicity of the modified TPR was studied by Fourier ...
Jianjian Song, Mingbiao Xu, Weihong Liu, Xiaoliang Wang, Peng Xu, Feng Huang, Yonggong Pan   +6 more
doaj   +2 more sources

Structural insights into the regulation of Cas7-11 by TPR-CHAT

Nature Structural & Molecular Biology, 2022
The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeats (TPR) fused with a CHAT domain).
Babatunde E. Ekundayo, D. Torre, B. Beckert, Sergey Nazarov, A. Myasnikov, Henning Stahlberg, D. Ni   +6 more
semanticscholar   +1 more source

TPR-TNR plot for confusion matrix

Communications for Statistical Applications and Methods, 2021
The two-dimensional confusion matrix used in credit assessment, biostatistics, and many other fields consists of true positive, true negative, false positive, and false negative. Their rates, such as the true positive rate (TPR), true negative rate (TNR),
Chong Sun Hong, Taekkyung Oh
semanticscholar   +1 more source

The Effectiveness of Total Physical Response (TPR) on Teaching English to Young Learners

Journal of Language Teaching and Research, 2021
This article through two teachers’ cases, namely, observation of two teachers’ classes and interview with them, interview with their students and their students’ parents, attempts to investigate the effectiveness of TPR as a classroom technique with ...
Rongxin Xie
semanticscholar   +1 more source

ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR

Cells, 2021
The nuclear basket (NB) scaffold, a fibrillar structure anchored to the nuclear pore complex (NPC), is regarded as constructed of polypeptides of the coiled-coil dominated protein TPR to which other proteins can bind without contributing to the NB’s ...
P. Gunkel, Haruki Iino, S. Krull, V. C. Cordes   +3 more
semanticscholar   +1 more source

Identification and Functional Analysis of Tomato TPR Gene Family

International Journal of Molecular Sciences, 2021
Tomato (Solanum lycopersicum) as an important vegetable grown around the world is threatened by many diseases, which seriously affects its yield. Therefore, studying the interaction between tomato and pathogenic bacteria is biologically and economically ...
Xinan Zhou, Yangyang Zheng, Zhibo Cai, Xingyuan Wang, Yang Liu, A. Yu, Xiuling Chen, Jiayin Liu, Yao Zhang, Aoxue Wang   +9 more
semanticscholar   +1 more source

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

Nature Communications, 2020
Nuclear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking, including genome organization and gene expression.
V. Aksenova, Alexandra Smith, Hangnoh Lee, Prasanna Bhat, Caroline Esnault, Shane Chen, J. Iben, R. Kaufhold, Ka Chun Yau, C. Echeverria, B. Fontoura, A. Arnaoutov, M. Dasso   +12 more
semanticscholar   +1 more source

TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes

Nucleic Acids Research, 2020
While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs generated from intronless genes use specific machinery to promote their export. Here, we investigate the role of the major nuclear pore basket protein, TPR, in
Eliza S. Lee, Eric J. Wolf, S. Ihn, Harrison. W. Smith, A. Emili, Alexander F. Palazzo   +5 more
semanticscholar   +1 more source

Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma

Autophagy, 2020
Children with ependymoma have high mortality rates because ependymoma is resistant to conventional therapy. Genomic and transcriptomic studies have identified potential targets as significantly altered genes in ependymoma patients.
F. Dewi, Shabierjiang Jiapaer, Akiko Kobayashi, M. Hazawa, Dini Kurnia Ikliptikawati, Hartono, H. Sabit, M. Nakada, R. Wong   +8 more
semanticscholar   +1 more source