Results 11 to 20 of about 59,328 (159)

Eomesodermin-expressing type 1 regulatory (EOMES+ Tr1)-like T cells: Basic biology and role in immune-mediated diseases [PDF]

, 2023
Type 1 regulatory (Tr1) T cells are currently defined all T cells with regulatory functions that lack FOXP3 expression and produce IL-10. Tr1 cells are heterogeneous, and the different reported properties of Tr1-cell populations have caused some ...
Grassi, Fabio, Abrignani, Sergio, Ylenia Silvestri, Carelli, Elena, Geginat, Jens, Scantamburlo, Morena, Paola Gruarin, Jens Geginat, Rossetti, Grazisa, Chiara Vasco, Gruarin, Paola, Raoul Bonnal, Bonnal, Raoul, Massimiliano Pagani, Vasco, Chiara, Monticelli, Silvia, Giorgia Moschetti, Pulvirenti, Nadia, Pagani, Massimiliano, Silvestri, Ylenia, Francesca Clemente, Silvia Monticelli, Clemente, Francesca, Elena Carelli, Fabio Grassi, Moschetti, Giorgia, Grazisa Rossetti, Nadia Pulvirenti, Sergio Abrignani, Morena Scantamburlo   +29 more
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Tr1-Like T Cells - An Enigmatic Regulatory T Cell Lineage [PDF]

, 2016
The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process.
Wraith, David
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In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. [PDF]

, 2011
Type 1 regulatory T (Tr1) cells, characterized by the secretion of high levels of the anti-inflammatory cytokine interleukin-10 (IL-10), play an important role in the regulation of autoimmune diseases and transplantation.
Starossom, S.C., Andre Pires da Cunha, Howard L. Weiner, da Cunha Andre Pires, Weiner, H.L., Benjamin T. Dake, Koeglsperger, T., Quintana Francisco J., Quintana, F.J., Francisco J Quintana, Thomas Koeglsperger, Benjamin T Dake, Francisco J. Quintana, Wu Henry Yim, Dake Benjamin T., Sarah C. Starossom, Dake, B.T., da Cunha, A.P., Henry Yim Wu, Koeglsperger Thomas, Howard L Weiner, Wu, H.Y., Sarah C Starossom, Starossom Sarah C., Weiner Howard L.   +24 more
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Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection [PDF]

, 2023
Published online: 14 June 2023Type I regulatory (Tr1) cells are defined as FOXP3−IL-10-secreting clusters of differentiation (CD4+) T cells that contribute to immune suppression and typically express the markers LAG-3 and CD49b and other co-inhibitory ...
Norton, T.S., Alsharifi, M., Mohammed Alsharifi, Pederson, S.M., Armstrong, M., Hill, G.R., Emily L Freimayer, Comerford, I., Stephen M Pederson, McColl, S.R., Aaron H S Heng, Zhipeng Qu, Iain Comerford, Qu, Z., Caitlin A Abbott, Freimayer, E.L., Geoffrey R Hill, H S Heng, A., Abbott, C.A., Todd S Norton, Timona S Tyllis, Tyllis, T.S., Mark Armstrong, Shaun R McColl   +23 more
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Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors [PDF]

, 2015
Item does not contain fulltextCD4+ type 1 T regulatory (Tr1) cells have a crucial role in inducing tolerance. Immune regulation by these cells is mainly mediated through the secretion of high amounts of IL-10.
Boor, P.P., Vargas-Mendez, E., Grünhagen, Dirk, Biermann, Katharina, Garcia-Romo, G.S., Mancham, S., Pedroza González, Alexander, Polak, Wojciech G, Kwekkeboom, J., Verhoef, C., Pan, Qiuwei, Sprengers, Dave, Janssen, Harry LA, Zhou, G., Polak, Wojciech G; id_orcid, Vargas Méndez, Ernesto, Kwekkeboom, Jaap, Ijzermans, J.N.M., Tjwa, Eric T. T. L., Biermann, K., Verhoef, Cornelis, Garcia-Romo, Gina S, Mancham, Shanta, Boor, Patrick P.C., Pan, Qiuwei; id_orcid, Pedroza-Gonzalez, A., Tjwa, Eric Ttl, IJzermans, Jan N. M., Polak, W.G., Grunhagen, D., Grünhagen, Dirk; id_orcid, García Romo, Gina S., Boor, Patrick Pc, Pan, Q., Zhou, Guoying, Sprengers, D., Polak, Wojciech G., Tjwa, E.T., Vargas-Mendez, Ernesto, IJzermans, Jan Nm, Janssen, H., Pedroza-Gonzalez, Alexander, Janssen, Harry L. A.   +42 more
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Summary of Trx redox status following TR1 knockdown and Sec-deficient TR1 expression: Percent Trx in each redox state (% total).

, 2013
Summary of the 6 possible redox states, from the most oxidized (state 1) to the least (state 6) of Trx in RKO cells with endogenous TR1 (si-Scramble), with endogenous TR1 knocked-down (si-TR1), or endogenous TR1 knocked-down but with induced Sec ...
Paul J. Shami (367727), Philip J. Moos (367728), Kornelia Edes (360526), Pamela Cassidy (367726)   +3 more
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ROS levels and HIF stabilization and activity in hypoxic TR1 over-expressing cells.

, 2012
ROS levels were determined in (A) EMT6 and (B) DT cells infected with retroviruses encoding the TR1 gene (TR1) or empty retroviruses (Ctrl) and cultured under normoxic (Nx) or hypoxic (Hx) conditions for 12 h.
Salvador Naranjo-Suarez (115256), Bradley A. Carlson (42825), Petra A. Tsuji (115254), Min-Hyuk Yoo (42823), Dolph L. Hatfield (13668), Vadim N. Gladyshev (8009)   +5 more
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Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology [PDF]

, 2016
Tumor necrosis factor (TNF) is critical for controlling many intracellular infections, but can also contribute to inflammation. It can promote the destruction of important cell populations and trigger dramatic tissue remodeling following establishment of
Sundar, S, Muller, W, Haque, A, Beattie, L, Sheel, M, Smyth, MJ, Faleiro, RJ, Engwerda, CR, Nutt, SL, Kallies, A, Ng, SS, Hill, GR, Bunn, PT, Montes de Oca, M, Kumar, R, Cretney, E, de Labastida Rivera, F, Best, SE, Amante, FH, Edwards, CL   +19 more
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Cell growth kinetics of RKO cells with modulated TR1 levels.

, 2013
A scrambled siRNA was used as a control to measure the basal growth rate (filled square) TR1 was knocked-down by siRNA (filled circle) and with induction of the Sec-deficient, C-terminal mutant TR1 (filled triangle).
Paul J. Shami (367727), Philip J. Moos (367728), Kornelia Edes (360526), Pamela Cassidy (367726)   +3 more
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Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplantation

, 2010
OBJECTIVE—In type 1 diabetes, allogeneic pancreatic islet transplant restores insulin production, but life-threatening immunosuppression is required to avoid graft rejection. Induction of antigen (Ag)–specific tolerance by cell therapy with regulatory
Stabilini A, Atkinson M, RONCAROLO , MARIA GRAZIA, Valle A, Gagliani N, Jofra T, BATTAGLIA, MARCO MARIA   +6 more
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