Results 31 to 40 of about 5,146 (128)
TR4 worsen urosepsis by regulating GSDMD
Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection.
Qiming Zheng +15 more
core +1 more source
Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. [PDF]
, 2014 We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular anchors for the recruitment of epigenetic corepressors of the multifaceted DRED complex, thereby ...
James Douglas Engel +32 more
core +1 more source
Community Dentistry and Oral Epidemiology, Volume 54, Issue 4, Page 471-479, August 2026.ABSTRACT Objectives The “valley of death” between research and practice remains a major challenge. The five‐stage Translational Research framework (TR1‐TR5) provides a pathway, moving evidence into real‐world impact. Traditionally, Randomised Controlled Trials (RCTs) dominate TR stages, yet they are often impractical in public health.
An T. M. Dao +4 more
wiley +1 more source
Der nukleäre Rezeptor TR4 induziert Myofibroblastendifferenzierung und Hautfibrose über eine Gα12/ROCK-abhängige Restrukturierung des Zytoskeletts [PDF]
Die systemische Sklerose (SSc) ist eine idiopathische, systemische, fibrotische Bindegewebserkrankung, die durch eine frühe Mikroangiopathie, eine Dysregulation des Immunsystems und eine daraus resultierende systemische Fibrose gekennzeichnet ist.
Shen, Lichong
core +1 more source
New Disease Reports, Volume 54, Issue 2, October/December 2026.
S. Pachacama +16 more
wiley +1 more source
Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source
Analysis of TR4 orphan nuclear receptor knockout mouse: roles of TR4 in glucose and lipid metabolism
, 2012 Thesis (Ph. D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Pathology and Laboratory Medicine, 2008.Testicular Receptor 4 (TR4, NR2C2), an orphan member of the nuclear receptor superfamily, is known to be involved in postnatal ...
Liu, Ning-Chun, Chang, Chawnshang
core
, 2012 Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Pathology and Laboratory Medicine, 2010.Testicular nuclear receptor 4 (TR4) is a member of the nuclear receptor superfamily.
Liu, Su, Chang, Chawnshang
core
, 2011 OBJECTIVE TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro.
Chawnshang Chang +7 more
core +1 more source
Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis
, 2012 Background Early studies suggested that TR4 nuclear receptor might play important roles in the skeletal development, yet its detailed mechanism remains unclear. Methods We generated TR4 knockout mice and compared skeletal development with their wild type
Chang Chawnshang +7 more
core +1 more source