TR4 nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression
, 2018 Early studies indicated that testicular nuclear receptor 4 (TR4) could function as a suppressor in the transcriptional regulation of the HBV core gene expression, which might then influence the development of hepatocellular carcinoma (HCC).
Chawnshang Chang +6 more
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The Protective Role of TR4 in Prostate Cancer
, 2013 Thesis (Ph.D.)--University of Rochester.School of Medicine & Dentistry. Dept. of Pathology and Laboratory Medicine, 2013.Testicular nuclear receptor 4 (TR4), a member of the nuclear receptor superfamily, plays important roles in metabolism, fertility ...
Lin, Shin-Jen, Chang, Chawnshang
core
TR4 and TR9 interfere with NF-κB signaling.
, 2016 HepG2 cells were transfected with the NF-κB reporter vector pB2LUC for 24 hours. The next day cells were either incubated with 5 μM TR3, TR4 or TR9 for 6 hours (A, white bars) or pre-incubated with limonoids for 2 hours followed by TNFα incubation for 4 ...
Claudia Wegscheid (168538) +7 more
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Uncontained spread of Fusarium wilt in banana caused by Fusarium odoratissimum TR4.
, 2022 (A) Banana is a major food crop in tropical and subtropical regions, especially in sub-Saharan Africa. In most major banana-producing regions, TR4 incursions have been reported (green dots), and TR4 is spreading globally from its Asian center of origin ...
Harold J. G. Meijer (7136474) +3 more
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Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease
, 2013 Cushing disease (CD) is a life-threatening disorder attributed to excess pituitary tumor-derived adrenocorticotrophic hormone (ACTH) and adrenal steroid secretion caused by pituitary tumors.
Jonker, Johan W.; id_orcid +9 more
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TR4 and TR9 inhibit proliferation of human hepatoma cells.
, 2016 A: HepG2 cells were incubated with 10 μM TR3, TR4 or TR9 for 20 hours. Cell proliferation was measured by BrdU-Assay. DMSO control: 0.1%. B: HepG2 cells were incubated with 5 μM TR3, TR4 or TR9 for 6 hours. Expression of PCNA, p21 and HSA was measured by
Claudia Wegscheid (168538) +7 more
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The Differential Effects of Anti-Diabetic Thiazolidinedione on Prostate Cancer Progression Are Linked to the TR4 Nuclear Receptor Expression Status [PDF]
, 2015 The insulin sensitizers, thiazolidinediones (TZDs), have been used as anti-diabetic drugs since the discovery of their ability to alter insulin resistance through transactivation of peroxisome proliferator-activated receptors (PPARs). However, their side
Lin, Chang-Yi +21 more
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Hippocalcin-like 4 (Hpcal4) expression in the spinal cord of naïve and TR4 mutant mice.
, 2020 Darkfield (Top) and brightfield (bottom) panels illustrate situ hybridization expression patterns of Hpcal4 mRNA in the lumbar spinal cord of naïve (WT) and TR4 mutant (KO) mice.
Hiroki Yamanaka (47976) +6 more
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TR4 and TR9 induce apoptosis in human hepatoma cells.
, 2016 HepG2 cells were incubated with 5 μM TR3, TR4 or TR9 for 24 hours. As an apoptosis induction control HepG2 cells were incubated with 80 nM ActD as well as 40 ng/ml TNFα (ActD/TNFα) for 16 hours.
Claudia Wegscheid (168538) +7 more
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In vivo monitoring of the TR4 anti-Notch fusion protein: an imaging approach.
, 2016 Presented in ASCO Annual Meeting, 2016, 3 June — 7 June, Chicago, United States of AmericaBackground: The Notch pathway has been associated with cancer and is implicated in tumorigenesis and regulation of cell fate.
Prokopi, Marianna +7 more
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