Results 81 to 90 of about 1,805,553 (348)

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]

, 2015
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P., Gronau, Julian H., King, Helen, Rodriguez-Teja, Mercedes, Shah, Neel, Sturge, Justin, Wang, Kai, Waxman, Jonathan   +7 more
core   +2 more sources

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

A digital model of trabecular bone

Journal of Bone and Mineral Research, 1996
Abstract A 3D μCT dataset of bovine bone was used to create a digital 3D model simulating trabecular bone. The model serves a dual purpose: It allows for standard quantitative histomorphometric analysis and it approximates the reality e.g. of high resolution CT in vivo datasets of trabecular bone.
K, Engelke, S M, Song, C C, Glüer, H K, Genant   +3 more
openaire   +2 more sources

Heme compounds in dinosaur trabecular bone [PDF]

Proceedings of the National Academy of Sciences, 1997
Six independent lines of evidence point to the existence of heme-containing compounds and/or hemoglobin breakdown products in extracts of trabecular tissues of the large theropod dinosaur Tyrannosaurus rex . These include signatures from nuclear magnetic resonance and electron spin resonance that indicate the ...
M H, Schweitzer, M, Marshall, K, Carron, D S, Bohle, S C, Busse, E V, Arnold, D, Barnard, J R, Horner, J R, Starkey   +8 more
openaire   +2 more sources

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats

BioMedical Engineering OnLine, 2019
Background Bone tissue displays a hierarchical organization. Mechanical environments influence bone mass and structure. This study aimed to explore the effects of different mechanical stimuli on growing bone properties at macro–micro–nano scales. Methods
Juan Fang, Jiazi Gao, He Gong, Tianlong Zhang, Rui Zhang, Bangchao Zhan   +5 more
doaj   +1 more source

A 3D trabecular bone homogenization technique

Acta of Bioengineering and Biomechanics, 2020
Purpose: Bone is a hierarchical material that can be characterized from the microscale to macroscale. Multiscale models make it possible to study bone remodeling, inducing bone adaptation by using information of bone multiple scales. This work proposes a computationally efficient homogenization methodology useful for multiscale analysis. This technique
Marco C, Marques, Jorge, Belinha, AntÓnio F, Oliveira, Maria Cristinha M, Cespedes, Renato M Natal, Jorge   +4 more
openaire   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Estimation of Trabecular Bone Volume with Dual-Echo Ultrashort Echo Time (UTE) Magnetic Resonance Imaging (MRI) Significantly Correlates with High-Resolution Computed Tomography (CT)

Journal of Imaging
Trabecular bone architecture has important implications for the mechanical strength of bone. Trabecular elements appear as signal void when imaged utilizing conventional magnetic resonance imaging (MRI) sequences.
Karen Y. Cheng, Dina Moazamian, Behnam Namiranian, Hamidreza Shaterian Mohammadi, Salem Alenezi, Christine B. Chung, Saeed Jerban   +6 more
doaj   +1 more source

Incorporating tissue anisotropy and heterogeneity in finite element models of trabecular bone altered predicted local stress distributions [PDF]

, 2017
Trabecular bone is composed of organized mineralized collagen fibrils, which results in heterogeneous and anisotropic mechanical properties at the tissue level.
Allen, Matthew R., Hammond, Max A., Siegmund, Thomas, Wallace, Joseph M.   +3 more
core   +1 more source