Results 121 to 130 of about 78,864 (334)

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui, F, Nakajima, R, Ideta, Y, Kaji, Y, Suzuki, M, Araie, S, Miyauchi, P, Heldin, H, Yamashita   +8 more
openaire   +2 more sources

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles

Scientific Reports, 2018
Glaucoma is a major cause of blindness and is frequently associated with elevated intraocular pressure. The trabecular meshwork (TM), the tissue that primarily regulates intraocular pressure, is known to have reduced cellularity in glaucoma.
Eric Snider, Kelsey P. Kubelick, K. Tweed, R. K. Kim, Yin Li, K. Gao, A. Read, S. Emelianov, C. Ethier   +8 more
semanticscholar   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

Review Of Applied Mathematical Models For Describing The Behaviour Of Aqueous Humor In Eye Structures

International Journal of Applied Mechanics and Engineering, 2015
In the paper, currently used methods for modeling the flow of the aqueous humor through eye structures are presented. Then a computational model based on rheological models of Newtonian and non-Newtonian fluids is proposed. The proposed model may be used
M. Dzierka, P. Jurczak
doaj   +1 more source

Endothelial nitric oxide synthase deficiency influences normal cell cycle progression and apoptosis in trabecular meshwork cells [PDF]

International Journal of Ophthalmology, 2016
AIM: To clarify how the endothelial nitric oxide synthase (eNOS, NOS3) make effect on outflow facility through the trabecular meshwork (TM). METHODS: Inhibition of NOS3 gene expression in human TM cells were conducted by three siRNAs.
Qiong Liao, Yan-Ming Huang, Wei Fan, Chan Li, Hong Yang   +4 more
doaj   +1 more source

Pharmacologic Manipulation of Conventional Outflow Facility in Ex Vivo Mouse Eyes [PDF]

, 2012
PURPOSE. Mouse models are useful for glaucoma research, but it is unclear whether intraocular pressure (IOP) regulation in mice operates through mechanisms similar to those in humans.
Bertrand, J, Boussommier-Calleja, A, Ethier, CR, Overby, DR, Stamer, WD, Woodward, DF   +5 more
core   +1 more source

Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model

Communications Biology, 2018
Glaucoma is the leading cause of irreversible vision loss, and reducing elevated intraocular pressure is currently the only effective clinical treatment.
Hongmin Yun, Yiwen Wang, Yiwen Wang, Yi Zhou, Yi Zhou, Ke Wang, Ming Sun, D. Stolz, X. Xia, C. Ethier, Yiqin Du   +10 more
semanticscholar   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork

Scientific Reports, 2018
To expand multi-potent progenitors from human trabecular meshwork (TM), we have created a new optimized method on two-dimensional (2D) followed by three–dimensional (3D) Matrigel in modified embryonic stem cell medium supplemented with 5% fetal bovine ...
Y. Zhang, S. Cai, S. Tseng, Ying-Ting Zhu   +3 more
semanticscholar   +1 more source