Results 301 to 310 of about 78,864 (334)

Regulation of Trabecular Meshwork Contractility

Ophthalmologica, 2000
Ample evidence supports the theory that trabecular meshwork possesses smooth-muscle-like properties. Trabecular meshwork cells express a large number of transporters, channels and receptors, many of which are known to regulate smooth-muscle contractility.
F, Stumpff, M, Wiederholt
openaire   +2 more sources

Matricellular proteins in the trabecular meshwork

Experimental Eye Research, 2009
The trabecular meshwork is one of the primary tissues of interest in the normal regulation and dysregulation of intraocular pressure (IOP) that is a causative risk factor for primary open-angle glaucoma. Matricellular proteins generally function to allow cells to modulate their attachments with and alter the characteristics of their surrounding ...
Douglas J, Rhee, Ramez I, Haddadin, Min Hyung, Kang, Dong-Jin, Oh   +3 more
openaire   +2 more sources

Trabecular meshwork and elastin

American Journal of Ophthalmology, 1996
Evidence that elastic fibers with elastin exists in the trabecular meshwork (TM) and play an important role in aqueous outflow resistance is presented. The elastic fibers consist of abundant microfibrillar components containing glycoproteins and amorphous components containing elastin.
openaire   +2 more sources

Mechanotransduction Channels of the Trabecular Meshwork

Current Eye Research, 2013
To determine whether the trabecular meshwork (TM), like the other organs engaged in filter like activities (such as kidneys), show the expression of known mechanotransduction channels at protein level.Human donor eye globes (n = 20), Donor eye derived TM tissue and primary TM cells were utilized for these studies.
Vu T, Tran, Phi T, Ho, Lais, Cabrera, Juan E, Torres, Sanjoy K, Bhattacharya   +4 more
openaire   +2 more sources

The development of human trabecular meshwork

Medical Electron Microscopy, 1994
The fetal development of the trabecular meshwork of the human eye was quantitatively studied by light and electron microscopy. From the 20th fetal week onward, the progressive thickening of the trabecular meshwork was achieved mainly by the widening of intertrabecular spaces, whereas the thickness and the number of trabeculae were almost constant ...
T, Sugiura, K, Mizokami, M, Yamamoto
openaire   +2 more sources

iPSCs-Based Therapy for Trabecular Meshwork

2023
The trabecular meshwork (TM) of the eye serves as an essential tissue in controlling aqueous humor (AH) outflow and intraocular pressure (IOP) homeostasis. However, dysfunctional TM cells and/or decreased TM cellularity is become a critical pathogenic cause for primary open-angle glaucoma (POAG). Consequently, it is particularly valuable to investigate
Wei, Zhu, Xiaoyan, Zhang, Shen, Wu, Ningli, Wang, Markus H, Kuehn   +4 more
openaire   +2 more sources

Mechanobiology of trabecular meshwork cells

Experimental Eye Research, 2009
Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces. Because the extent of mechanical stress on the trabecular meshwork is dependent on the intraocular pressure, the behavior of TM cells ...
openaire   +2 more sources

Trabecular meshwork ECM remodeling in glaucoma: could RAS be a target?

Expert opinion on therapeutic targets, 2018
Introduction: Disturbances of extracellular matrix (ECM) homeostasis in trabecular meshwork (TM) cause increased aqueous outflow resistance leading to elevated intraocular pressure (IOP) in glaucomatous eyes.
Puneet Agarwal, R. Agarwal
semanticscholar   +1 more source

Endothelin receptor B in trabecular meshwork

Experimental Eye Research, 2007
Endothelin-1 (ET-1), the most potent vasoconstrictor known to date, seems to be involved in the pathogenesis of primary open angle glaucoma. ET-1 was found in different tissues of the eye and in high concentrations in the aqueous humour. The effects of ET-1 are mediated by two receptors, ET-A receptor (ET-AR) and ET-B receptor (ET-BR), which are both ...
Rita, Rosenthal, Lars, Choritz, Rüdiger, Zorn, Galina, Münzer, Michael, Fromm, Norbert, Pfeiffer, Hagen, Thieme   +6 more
openaire   +2 more sources

Histopathologic Examination of Trabecular Meshwork Changes After Trabecular Bypass Stent Implantation

Journal of glaucoma, 2018
Purpose: The purpose of this article was to evaluate how human trabecular meshwork (TM) is influenced by the chronic presence of trabecular bypass implants.
Cara E. Capitena Young, D. Ammar, Leonard K. Seibold, M. Pantcheva, J. Soohoo, M. Kahook   +5 more
semanticscholar   +1 more source