Results 81 to 90 of about 3,238 (205)

Ocular hypotension, actin stress fiber disruption and phagocytosis increase by RKI-1447, a Rho-kinase inhibitor [PDF]

, 2018
Objective: The Rho GTPase/Rho kinase pathway is an important target in glaucoma treatment. This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor developed for cancer treatment, in a porcine ex vivo pigmentary glaucoma model.
Dang, Yalong, Loewen, Nils A., Loewen, Ralitsa T., Shah, Priyal, Wang, Chao, Waxman, Susannah   +5 more
core   +1 more source

Rigid Probe Trabeculotomy Versus 360-Degree Catheter Trabeculotomy in Childhood Glaucoma

Journal of Clinical Medicine
Background/Objectives: This study aims to compare the effectiveness of traditional rigid probe trabeculotomy and 360-degree catheter trabeculotomy in treating childhood glaucoma, underlining the necessity of early surgical intervention. Methods: This retrospective cohort study, conducted at the University Eye Hospital Mainz, Germany, included 109 ...
Felix Mathias Wagner, Paul Oster, Julia Veran Stingl, Alexander Karl-Georg Schuster, Jasmin Rezapour, Angi Liz Mendoza-Moreira, Achim Fieß, Anke Messerschmidt-Roth, Franz Grehn, Norbert Pfeiffer, Esther Maria Hoffmann   +10 more
openaire   +2 more sources

DDX58 variant triggers IFN‐β‐induced autophagy in trabecular meshwork and influences intraocular pressure

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
DDX58 variant‐induced IFN‐β regulates autophagy in TM cells via RSAD2 and influences IOP in atypical SMS. In healthy TM cell, RIG‐I does not recognize self‐dsRNA, thus preventing triggering downstream signaling. In TM cells of atypical SMS, SMS‐RIG‐I recognizes and continuously binds self‐dsRNA, leading to the activation of MAVs and downstream ...
Xinting Huang, Xiaoyu Zhou, Feng Zhang, Xiaobo Wang, Xuanchu Duan, Ke Liu   +5 more
wiley   +1 more source

Primary cilia signaling mediates intraocular pressure sensation [PDF]

, 2014
Lowe syndrome is a rare X-linked congenital disease that presents with congenital cataracts and glaucoma, as well as renal and cerebral dysfunction. OCRL, an inositol polyphosphate 5-phosphatase, is mutated in Lowe syndrome.
Cantor, Louis B., Chen, Xingjuan, Conwell, Michael D., Corson, Timothy W., Iomini, Carlo, Joos, Karen M., Kettenhofen, Christine Insinna, Luo, Na, Obukhov, Alexander G., Spandau, Dan F., Sun, Yang, Weinreb, Robert N., Wells, Clark D., Westlake, Christopher J.   +13 more
core   +2 more sources

Long‐term functional and structural outcomes in patients with primary congenital glaucoma—A Danish nationwide study

Acta Ophthalmologica, Volume 102, Issue 2, Page 228-237, March 2024.
Abstract Purpose Evaluation of long‐term functional and structural outcomes in patients with primary congenital glaucoma (PCG) based on visual acuity (VA), visual field (VF) using standard automated perimetry, and peripapillary retinal nerve fibre layer thickness (pRNFL).
Troels Brynskov, Daniella Bach‐Holm, Per Kappelgaard, Volkert Siersma, Karen Bjerg Pedersen, Line Kessel   +5 more
wiley   +1 more source

Canaloplasty and Trabeculotomy Combined with Phacoemulsification for Glaucoma: 12-Month Results of the GEMINI Study

Clinical Ophthalmology, 2022
Mark J Gallardo,1 Mark F Pyfer,2 Steven D Vold,3 Steven R Sarkisian Jr,4 Anita Campbell,5 Inder Paul Singh,6 Brian Flowers,7 Kavita Dhamdhere8 On behalf of the GEMINI study group1El Paso Eye Surgeons, PA, El Paso, TX, USA; 2Northern Ophthalmic Associates,
Gallardo MJ, Pyfer MF, Vold SD, Sarkisian SR Jr, Campbell A, Singh IP, Flowers B, Dhamdhere K   +7 more
doaj  

Surgical management of primary congenital glaucoma in egypt

Journal of the Egyptian Ophthalmological Society, 2016
Purpose To study primary congenital glaucoma characteristics and surgery in a University-based practice in Egypt. Patients and methods The present study was a retrospective chart review of 165 eyes of 112 children who presented and were operated upon ...
Nader H.L. Bayoumi
doaj   +1 more source

ARC syndrome accompanied with glaucoma in one of two affected siblings

Pediatrics International, Volume 67, Issue 1, January/December 2025.
Takashi Okuno, Motohiro Takeuchi, Sachi Shimizu, Naoko Hiragi, Yusei Ohshima   +4 more
wiley   +1 more source

Genetic risk of glaucoma is associated with vascular and retinal nerve fibre wedge defects

Acta Ophthalmologica, Volume 102, Issue 2, Page e185-e194, March 2024.
Abstract Purpose To evaluate the association between localised vascular and retinal nerve fibre layer (RNFL) loss and genetic risk for glaucoma and cardiovascular disease using polygenic risk scores (PRS). Methods 858 eyes were included from 455 individuals with suspect and early manifest primary open angle glaucoma.
Danit G. Saks, Angela Schulz, Ayub Qassim, Henry Marshall, Alex W. Hewitt, Stuart MacGregor, Jamie E. Craig, Stuart L. Graham   +7 more
wiley   +1 more source

Suppression of Diurnal (9AM–4PM) IOP Fluctuations with Minimally Invasive Glaucoma Surgery: An Analysis of Data from the Prospective, Multicenter, Single-Arm GEMINI Study

Clinical Ophthalmology, 2021
Mark F Pyfer,1 Mark Gallardo,2 Anita Campbell,3 Brian E Flowers,4 Jaime E Dickerson Jr,5,6 Alain Talla,5 Kavita Dhamdhere5,7 1Northern Ophthalmic Associates, Jenkintown, PA, USA; 2El Paso Eye Surgeons, PA, El Paso, TX, USA; 3Grene Vision Group, Wichita ...
Pyfer MF, Gallardo M, Campbell A, Flowers BE, Dickerson Jr JE, Talla A, Dhamdhere K   +6 more
doaj