Results 61 to 70 of about 1,280,662 (255)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Comparison of Contrasting Prolog Trace Output Formats [PDF]
, 1997 This paper reports on a comparative study of three Prolog trace packages. 43 students of an introductory Prolog course solved 5 different Prolog programming problems in each of three different conditions (using isomorphic problem variants to disguise ...
Patel, Mukesh J. +5 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Canadian Journal of Learning and Technology, 2018 Cet article présente une étude qualitative de l’usage de ressources numériques d’un cours universitaire de formation d’enseignants d’espagnol au Chili. L’analyse compte 3882 traces laissées sur le site Web Didactique de Langue Castillane (DLC), sur une ...
Sandra Meza Fernández, Pascal Marquet
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2001 Selenium as well as copper, zinc, and manganese play an important role in the detoxification of free radicals. There might be possible interactions with the mechanisms of action for cytostatic drugs as well as ionizing radiation.
Arbeitskreis Trace Elements and Electrolytes in Radiation Oncology (AKTE) (Germany)
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2012 The purpose of this article is to consider the function of traces in Mark Twain's representation of the West in Roughing It. Through the humorous appropriation of the topographical, literary and iconographic markings which provide the landscape with its ...
Delphine Louis-Dimitrov
doaj +1 more source
Fluvial contributions of nutrient salts, dissolved trace elements and organic carbon to the sea by pristine temperate rivers (SW Europe). [PDF]
, 2013 Bernárdez, P., Ospina-Alvarez, N., Caetano, M., & Prego, R. (2013). Fluvial contributions of nutrient salts, dissolved trace elements and organic carbon to the sea by pristine temperate rivers (SW Europe). Environmental Chemistry, 10(1), 42–53. doi:http:/
R. Prego +10 more
core +1 more source