Results 61 to 70 of about 659,480 (265)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2012 The purpose of this article is to consider the function of traces in Mark Twain's representation of the West in Roughing It. Through the humorous appropriation of the topographical, literary and iconographic markings which provide the landscape with its ...
Delphine Louis-Dimitrov
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
L’écologie déséquilibrante de l’oubli chez Homo Numericus
Netcom, 2012 The aim of this paper is to construct the problematics of the just balance between the memory and the forgetting in the digital era, which is in danger with the coming of the digital technology which memorizes everything while never forget.
Sung do Kim
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
LA POSICIÓN DEL «AGENTE RETENEDOR» EN LOS MODELOS DE INTERCAMBIO DE INFORMACIÓN: ¿SUSTITUTO O COLABORADOR? [PDF]
Crónica Tributaria, 2015 El presente artículo tiene como objetivo analizar la figura del «intermediario» o «agente retenedor/pagador» que sale a relucir en los nuevos modelos de intercambio de información –FATCA, Rubik, TRACE, las Directivas europeas– con el fin de desvelar qué ...
Marina Serrat Romaní
doaj
Traces et espaces de consommation
Netcom, 2016 The advent of mobile digital technologies has contributed to an evolution in the modalities of distribution and consumption. The present article focuses on the use of QR-codes, these two-dimensional barcodes which give every user equipped with a ...
Franck Cochoy, Jan Smolinski
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source