Results 41 to 50 of about 460,542 (309)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Enhanced age-hardening in a lean Mg-Al-Ca-Mn alloy by trace silver addition

Materials Research Letters
Promoting the precipitation of Guinier-Preston (G.P.) zones in fast-extruded Mg-Al-Ca-Mn alloys could enhance the age-hardenability, which remains a significant challenge.
Zhao-Yuan Meng, Hai-Long Jia, Hong Ju, Shen-Bao Jin, Kai Guan, Cheng Wang, Min Zha, Hui-Yuan Wang   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Effect of trace germanium on microstructure and quenching sensitivity of 7056 aluminum alloy

Cailiao gongcheng, 2019
The effect of trace Ge on the microstructure and quenching sensitivity of 7056 aluminum alloy was studied by mechanical tensile and end quenching experiments, combined with some analysis methods such as metallographic observation, hardness test ...
LI Wei, CHEN Kang-hua, JIAO Hui-bin, ZHOU Liang, YANG Zhen, CHEN Song-yi   +5 more
doaj   +1 more source

Investigating Sintering Mechanisms for Additive Manufacturing of Conductive Traces

American Journal of Engineering and Applied Sciences, 2018
Additive Manufacturing (AM) processes enable the fabrication of miniaturized and flexible devices on complex geometries. This paper explores a hybrid additive manufacturing technology that integrates micro-extrusion and PICO-jetting methods. Conductive slurries and colloidal inks were optimized for their rheological properties to aid their precise ...
Jasmine McKenzie, Salil Desai
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Trace elements affect methanogenic activity and diversity in enrichments from subsurface coal bed produced water

Frontiers in Microbiology, 2012
Microbial methane from coal beds accounts for a significant and growing percentage of natural gas worldwide. Our knowledge of physical and geochemical factors regulating methanogenesis is still in its infancy. We hypothesized that in these closed systems,
Burcu eÜnal, Verlin Ryan Perry, Mili eSheth, Vicente eGomez-Alvarez, Kuk-Jeong eChin, Klaus eNüsslein   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effect of trace silver addition on microstructure and properties of Cu-0.45Cr-0.1Zr alloy

Journal of Materials Research and Technology
Cu-0.45Cr-0.1Zr-(0.3Ag) were produced and subjected to multistage thermo-mechanical treatment. The microstructure evolution and properties of the alloys during aging were investigated in detail and the effect of trace Ag on comprehensive properties of Cu–
Xinfeng Jiang, Zhu Xiao, Zhou Li, Xiaopeng Liang   +3 more
doaj   +1 more source