Results 61 to 70 of about 460,542 (309)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Trace nano-Ti addition for graphene nanoplatelets/copper composites to simultaneously enhance strength-ductility and wear resistance

Journal of Materials Research and Technology
Graphene nanoplatelets (GNPs)/copper composites containing nano-Ti addition were prepared using the vacuum hot-pressing sintering process. The effect of Nano-Ti on microstructure and mechanical properties of GNPs/copper composite was investigated. Before
Xinjiang Zhang, Ming Yang, Cailiu Yin, Jianlie Liang, Meng He, Zirun Yang   +5 more
doaj   +1 more source

On Skew Centralizing Traces of Permuting n-Additive Mappings

Kyungpook mathematical journal, 2015
Let R be a ring and D : R n ! R be n-additive mapping. A map d : R ! R is said to be the trace of D if d(x) = D(x;x;:::x) for all x 2 R: Suppose that ; are endomorphisms of R. For any a;b 2 R, let (; )= a (b) + (b)a. In the present paper under certain suitable torsion restrictions it is shown that D = 0 if R satises either (; )= 0, for all x 2 R or (
Mohammad Ashraf, Nazia Parveen
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effect of Li addition on the precipitation behavior of AA6061 alloy

Journal of Materials Research and Technology
This study investigates the effect of minor Li addition on the solute clustering and thermal stability of precipitates in artificially aged Al–Mg–Si–Cu (AA6061) alloys.
Hyeon-Woo Son, Sung-Ho Kang, Kwangjun Euh, Yun-Soo Lee, Kyoungdoc Kim   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

On Traces of n-Additive Mappings on Semiprime Ring

Journal of Advances in Applied & Computational Mathematics, 2017
 Let R be a ring with centre Z(R). In this paper we prove that a nonzero Lie ideal L of a semiprime ring R of characteristic different from (2n-2) is central if it satisfies one of the following: (i)f(xy)∓[x,y]∈Z(R), (ii)f(xy)∓[y,x]∈Z(R), (iii)f(xy)∓xy∈Z(R), (iv)f(xy)∓yx∈Z(R), (v)f([x,y] )∓[x,y]∈Z(R), (vi)f([x,y] )∓[y,x]∈Z(R), (vii)f([x,y] )∓xy∈Z(R ...
null Asma Ali, null Najat Muthana, null Kapil Kumar   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source