Results 81 to 90 of about 1,844,938 (269)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Trace nano-Ti addition for graphene nanoplatelets/copper composites to simultaneously enhance strength-ductility and wear resistance

Journal of Materials Research and Technology
Graphene nanoplatelets (GNPs)/copper composites containing nano-Ti addition were prepared using the vacuum hot-pressing sintering process. The effect of Nano-Ti on microstructure and mechanical properties of GNPs/copper composite was investigated. Before
Xinjiang Zhang, Ming Yang, Cailiu Yin, Jianlie Liang, Meng He, Zirun Yang   +5 more
doaj   +1 more source

On Skew Centralizing Traces of Permuting n-Additive Mappings

Kyungpook mathematical journal, 2015
Let R be a ring and D : R n ! R be n-additive mapping. A map d : R ! R is said to be the trace of D if d(x) = D(x;x;:::x) for all x 2 R: Suppose that ; are endomorphisms of R. For any a;b 2 R, let (; )= a (b) + (b)a. In the present paper under certain suitable torsion restrictions it is shown that D = 0 if R satises either (; )= 0, for all x 2 R or (
Mohammad Ashraf, Nazia Parveen
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effect of Li addition on the precipitation behavior of AA6061 alloy

Journal of Materials Research and Technology
This study investigates the effect of minor Li addition on the solute clustering and thermal stability of precipitates in artificially aged Al–Mg–Si–Cu (AA6061) alloys.
Hyeon-Woo Son, Sung-Ho Kang, Kwangjun Euh, Yun-Soo Lee, Kyoungdoc Kim   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

One Bad Apple Spoils the Bunch: Exploiting P2P Applications to Trace and Profile Tor Users [PDF]

, 2011
Tor is a popular low-latency anonymity network. However, Tor does not protect against the exploitation of an insecure application to reveal the IP address of, or trace, a TCP stream.
Abdelberi, Chaabane, Blond, Stevens Le, Castelluccia, Claude, Dabbous, Walid, Kaafar, Mohamed Ali Dali, Legout, Arnaud, Manils, Pere   +6 more
core   +3 more sources

On Traces of n-Additive Mappings on Semiprime Ring

Journal of Advances in Applied & Computational Mathematics, 2017
 Let R be a ring with centre Z(R). In this paper we prove that a nonzero Lie ideal L of a semiprime ring R of characteristic different from (2n-2) is central if it satisfies one of the following: (i)f(xy)∓[x,y]∈Z(R), (ii)f(xy)∓[y,x]∈Z(R), (iii)f(xy)∓xy∈Z(R), (iv)f(xy)∓yx∈Z(R), (v)f([x,y] )∓[x,y]∈Z(R), (vi)f([x,y] )∓[y,x]∈Z(R), (vii)f([x,y] )∓xy∈Z(R ...
null Asma Ali, null Najat Muthana, null Kapil Kumar   +2 more
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source