Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
Analytical Performances of Polymer-Based Biosensors for Real Samples Application. [PDF]
Biosensors (Basel)Mascini M +4 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Palladium-Catalyzed Synthesis of 5‑Formyl-2'-Deoxycytidine, 5‑Carboxyl-2'-Deoxycytidine, and Nitrogen-15-Labeled Derivatives via Ex Situ-Generated Carbon Monoxide from Chloroform and Application in Isotope Dilution LC-MS/MS Analysis of DNA. [PDF]
ACS OmegaStefoudi E, Terzidis MA.
europepmc +1 more source
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
An Exploratory Study of High-Concentration Trace Amine Effects and Adrenoceptor Expression Patterns in SH-SY5Y Cells and Neuroblastoma. [PDF]
Int J Mol SciLopachev AV +4 more
europepmc +1 more source
Advanced Science, EarlyView.SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu +8 more
wiley +1 more source
Anticancer potential of radioactively activated zinc: mechanisms and therapeutic applications. [PDF]
Sci RepKalındemirtaş FD +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
Trace Elements and Viral Infectious Diseases: Dual Roles in Pathogenesis and Immunity. [PDF]
Infect Dis RepMedeiros CMDS +4 more
europepmc +1 more source