Results 101 to 110 of about 368,022 (299)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Exploiting CO2:CO correlations from aircraft concentration data in a regional atmospheric inversion [PDF]

, 2006
Observed correlations between atmospheric concentrations of CO2 and CO represent potentially powerful information for improving CO2 surface flux estimates through coupled CO2-CO inverse analyses.
Vay, Stephanie A., Glen W. Sachse, Palmer, P. I., Jacob, Daniel, Vay, S. A., Parvadha Suntharalingam, Jacob, D. J., David G. Streets, Dylan B. A. Jones, Fu, Qingyan, Daniel J. Jacob, Streets, D. G., Palmer, Paul I., Paul I. Palmer, Fu, Q. Y., Sachse, G. W., Jones, Dylan B.A., Stephanie A. Vay, Jones, Dylan B. A., Jacob, Daniel J., Streets, David G., Qingyan Fu, Suntharalingam, P., Jones, D. B. A., Sachse, Glen W., Suntharalingam, Parvadha   +25 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Trace evidence? The term trace from adjective to noun

WIREs Forensic Science, 2019
AbstractUnfortunate inconsistency and confusion exists with respect to the term trace evidence. With the term trace evidence, “trace” is commonly used as an adjective to connote the small size of materials (often microscopic) that can be used to aid in an investigation by providing linkages, or associations, between potential suspects, victims, and ...
Patrick Buzzini, Brooke W. Kammrath, Peter De Forest   +2 more
openaire   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Statistical modeling and analysis of trace element concentrations in forensic glass evidence

, 2018
The question of the validity of procedures used to analyze forensic evidence was raised many years ago by Stephen Fienberg, most notably when he chaired the National Academy of Sciences’ Committee that issued the report The Polygraph and Lie Detection ...
Kafadar, Karen, Pan, Karen
core  

Statistical support for weight of evidence determinations of handwriting evidence

, 2021
Handwriting analysis is conducted through the expertise of Forensic Document Examiners (FDEs) by visually comparing writing samples. Through their training and years of experience, FDEs are able to recognize critical characteristics of writing to ...
Ommen, Danica, Johnson, Madeline
core  

Biogeochemical cycling of carbon, water, energy, trace gases and aerosols in Amazonia: The LBA Eustach experiments. [PDF]

, 2002
The biogeochemical cycling of carbon, water, energy, aerosols, and trace gases in the Amazon Basin was investigated in the project European Studies on Trace Gases and Atmospheric Chemistry as a Contribution to the Large-Scale Biosphere-Atmosphere ...
Almeida, S.S. de, von Jouanne, J., Lourdes Ruivo, M.A. de, Andreae, M.O., Culf, A. D., Culf, A.D., Manzi, A., M. O. Andreae, A. D. Nobre, Manzi, A.O., Silva-Dias, M.A., Nobre, Antonio Donato, Nobre, C., C. Nobre, M. J. Waterloo, Artaxo, P., Costa, A. L., F. X. Meixner, Grace, J., Jouanne, J., von, P. Ciccioli, da Costa, A., Ciccioli, P., Waterloo, M., C. Brandão, Silva-Dias, M.A.F. da, Culf, A., Andreae, M. O., Waterloo, M. J., Meixner, F.X., J. Grace, Silva-Dias, M. A., Carswell, F.E., Costa, A.L., da, de Almeida, S.S., Gash, J.H.C., P. Kabat, da Costa, A.L., J. L. Esteves, Esteves, J.L., M. A. Silva‐Dias, Carswell, F. E., Manzi, A. O., Esteves, J., Carswell, F., de Lourdes Ruivo, M., P. Stefani, Manzi, Antonio Ocimar, F. E. Carswell, A. O. Manzi, J. von Jouanne, Waterloo, M.J., A. D. Culf, Kabat, P., M. d. L. P. Ruivo, Nobre, Carlos Afonso, Valentini, R., Jouanne, J. von, Nobre, A. D., Lelieveld, J., da Silva-Dias, M.A.F., Ruivo, M., Ruivo, M.L.P., Gash, J., Nobre, A., da Costa, A. L., Ruivo, M. D. L. P., Silva Dias, Maria Assuncao, Y. Malhi, Andreae, M., Gash, J. H. C., J. H. C. Gash, J. Lelieveld, Brandao, C., Nobre, C.A., R. Valentini, Meixner, F. X., Lourdes Ruivo, M., de, P. Artaxo, Silva-Dias, M., Meixner, F., Nobre, A.D., Esteves, J. L., de Lourdes Ruivo, M.A., A. L. da Costa, Malhi, Y., Stefani, P.   +86 more
core   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source