Results 41 to 50 of about 6,801,451 (249)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
This is a sample submission generated by Vireo to test the repository deposit ...
Submitter, Test
core +5 more sources
Genesis of karst groundwater contamination based on system spatial feature recognition
地质科技通报, 2022 The karst groundwater system has a complex spatial structure, strong aquifer permeability and poor anti-pollution performance. Once pollution occurs, the pollutants spread rapidly, and the repair is difficult.
Hang Ning +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Water Resources ResearchFractures are ubiquitous in reservoirs used for geothermal heat extraction, CO2 storage, and other subsurface applications. Their significant impact on flow and transport requires accurate characterization for performance estimation and risk assessment ...
Michael Liem +3 more
doaj +1 more source
Tracer-Test Design for Losing Stream–Aquifer Systems. [PDF]
International Journal of Speleology, 2006 Hydrological tracer testing is an effective way for assessing the significance and extent of leakage through the bed of an influent(losing and sinking) stream.
Field Malcolm S.
doaj
Karst hydrogeological survey and tracing of Zhangyukeng phosphogypsum repository
Carsologica Sinica, 2023 The most effective treatment of phosphogypsum—the waste generated in the production of phosphoric acid—is centralized landfill. Given the stability of phosphogypsum landfill and possible pollution to groundwater, Zhangyukeng phosphogypsum repository, a ...
Zhihao ZHAO +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Investigation of Liquid Channeling in Heap by Tracer Test
Journal of MMIJ, 2017 This paper describes channeling of liquid flow in copper ore heaps used for chemical or bio- leaching. The size of packed beds utilized as heap is 5 by 5 meters and the height is 3.5 or 5 meters.
Tatsuya SHINKAWA +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source