Results 61 to 70 of about 376,028 (266)

L’héritage familial de la Shoah : approches et perspectives des historiens et des romanciers [PDF]

open access: yesSvět Literatury
The memory of the Holocaust has been long shaped by the testimonies of camp survivors or other witnesses of the times rather than by historians. Over time, the perspective of the victims continues to dominate research, but eyewitnesses are no longer ...
Silvia Rybárová
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Fossils, Modality & Central Subjects in Palaeobiological Reconstruction

open access: yesPhilosophy, Theory, and Practice in Biology
Paleobiology is not only a science of the deep past: it is a science of deep possibility. Drawing on recent speculative reconstructions of Spinosaurus aegyptiacus, I sketch a new account of paleobiological reconstruction.
Adrian Currie
doaj   +2 more sources

Marquage ou contrainte ? Regard heuristique sur les usages du concept de point de vue

open access: yesCorela, 2016
This paper aims to highlight the importance Pierre-Yves Raccah gave to the concept of point of view, it being crucial for the internal development of semantics.
Zsuzsa Simonffy
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Research of motorcycle braking parameters / Motociklo stabdymo efektyvumo tyrimas

open access: yesMokslas: Lietuvos Ateitis, 2016
From a technical point of view, in dangerous or emergency situation is very important motorcycle driver reaction and vehicle braking time. Motor-cycle deceleration parameters depend not only on the motorcycle brake system, but also on the driving ...
Loreta Levulytė   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

L'experience d'ecrire: construction d'un lieu extra-topique

open access: yesPsicologia & Sociedade, 2009
Dans cet article, il s'agira de travailler l'écriture comme lieu des reviviscences des événements de temps (sensations anciennes non encore psychisées).Dans ce temps du récit, de l'écriture de soi, tout devient image, tout se projette au-devant dans l ...
Céline Masson
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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