Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Introduction: Despite multiple outbreaks annually, Uganda still lacks a national anthrax control program. While the surrounding districts of Gomba, Kazo, and Kiruhura had experienced anthrax outbreaks previously, Sembabule had not documented any.
Hannington Katumba +11 more
doaj +1 more source
Effect of Using Fartlek Techniques to Control the Rhythm of Running for 1500 m Runners [PDF]
This coach could define a specific technique to operate the Fartlek and he innovated some model examples such as the Fartlek short way, the Fartlek long way, the downward Fartlek, the upward Fartlek and the hierarchical Fartlek).
Hassan Ibrahim Abd El-Hamid Abou El-Magd
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Magnetic Field Based Hand Tracking
Sensor-based 3D hand tracking is still challenging despite the massive exploration of different sensing modalities in the past decades. This work describes the design, implementation, and evaluation of a novel induced magnetic field-based 3D hand tracking system, aiming to address the shortcomings of existing approaches and supply an alternative ...
Sizhen Bian +4 more
openaire +3 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
IntroductionSpectator attendance at the national athletics championships in Slovakia has been low for a long time, despite free admission. Not even the elevated performance of Slovak athletes in certain disciplines and the growing media interest in ...
Monika Písečná, Iveta Cihová
doaj +1 more source
The effect of a training program Using Proprioceptive Neuromuscular Facilitation (PNF) on the improvement the special physical abilities and numerical level for an 110Meter Hurdles Juniors [PDF]
The researcher noted deficiencies of some juniors in the stage of crossing the hurdle in the championship of the Republic under (18) years old, which in turn affects the numerical level; the researcher has attributed this to the low level of ...
Ramy Salem
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Determinants of Mental Toughness and Their Relationship to the Numerical Level of Middle Distance Runners [PDF]
The objective of this research was to identify the level of Mental Toughness (high- medium- low) and the relationship between dimensions of Mental Toughness and the numerical level in middle distance runners. The researcher used the descriptive method on
Mohammed Mostafa Awad
doaj +1 more source

