Results 51 to 60 of about 686,506 (283)
Nested Multi- and Many-Objective Optimisation of Team Track Pursuit Cycling
Frontiers in Applied Mathematics and Statistics, 2016 Team pursuit track cycling is an elite sport that is part of the Summer Olympics. Teams race against each other on special tracks called velodromes. In this article, we create racing strategies that allow the team to complete the race in as little time ...
Markus Wagner
doaj +1 more source
A mathematical model for simulating cycling: applied to track cycling [PDF]
Sports Engineering, 2018 A review of existing mathematical models for velodrome cycling suggests that cyclists and cycling coaches could benefit from an improved simulation tool. A continuous mathematical model for cycling has been developed that includes calculated slip and steering angles and, therefore, allows for resulting variation in rolling resistance. The model focuses
Billy Fitton, Digby Symons
openaire +1 more source
Effect of detraining on bone and muscle tissue in subjects with chronic spinal cord injury after a period of electrically-stimulated cycling: a small cohort study [PDF]
, 2009 Objective: To investigate adaptive changes in bone and muscle parameters in the paralysed limbs after de-training or reduced functional electrical stimulation (FES) induced cycling following high-volume FES-cycling in chronic spinal cord injury (SCI ...
Kakebeeke, T.H. +19 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Journal of Differential Equations, 1986 This article uses analytic geometry methods to bound the number of limit cycles of bounded period for a planar polynomial vector fields. It introduces the notion of limit periodic sets and shows that the Hilbert's 16th problem can be reduced to the existence of a uniform bound on its cyclicity.
Françoise, Jean-Pierre, Pugh, C.C
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Clinical relevance and treatment possibilities of bipolar rapid cycling [PDF]
, 2002 Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness.
Amann, B. +4 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source