Results 71 to 80 of about 686,506 (283)

Bicycling tasks relation to stability measures during alcohol intoxication

Traffic Safety Research
Bicycling accidents are a major traffic safety problem and are deemed ‘an unacceptable human and social price for EU citizens’. One of the major causes for bicycling accidents is loss of balance. A related influencing factor is alcohol intoxication.
Jan Andersson, Henriette Wallén Warner, Peter Andrén   +2 more
doaj   +1 more source

Sprinting After Having Sprinted: Prior High-Intensity Stochastic Cycling Impairs the Winning Strike for Gold

Frontiers in Physiology, 2019
Bunch riding in closed circuit cycling courses and some track cycling events are often typified by highly variable power output and a maximal sprint to the finish. How criterium style race demands affect final sprint performance however, is unclear.
Naroa Etxebarria, Steve A. Ingham, Richard A. Ferguson, David J. Bentley, David B. Pyne, David B. Pyne   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cycle Track

Informes de la Construccion, 1968
This track was specially built for the Olympic Games, and there is room for 5.951 spectators. There is also room for parking 700 cars. Access to the stands is on street level, and there are stairs which reach half the full height of the stands. The track, 333.33 m long, and 7 m wide, was made with African «Doussie» timber, and rests on wood structures,
Escalante, J., Escalante, I., Escalante, A.   +2 more
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Nature Communications, 2019
Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation ...
Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo   +9 more
doaj   +1 more source

Cycle Track Safety Remains Unproven

American Journal of Public Health, 2013
Lusk et al. claim that American Association of State Highway and Transportation Officials (AASHTO) guidelines discourage "physically separated and bicycle-exclusive paths adjacent to sidewalks."(1) In fact, these guidelines prohibit bicycle lanes on the roadway separated from travel lanes by parked cars or a raised barrier.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Comparison of stimulation patterns for FES-cycling using measures of oxygen cost and stimulation cost [PDF]

, 2006
<b>Aim</b><p></p> The energy efficiency of FES-cycling in spinal cord injured subjects is very much lower than that of normal cycling, and efficiency is dependent upon the parameters of muscle stimulation.
Stone, B., Grant, S., Hunt, K.J., Fraser, M.H., Allen, D.B., Ferrario, C., McLean, A.N.   +6 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source