Results 31 to 40 of about 23,225 (270)

Geometry and stiffness optimization for switches and crossings, and simulation of material degradation

, 2010
A methodology for simulating wear, rolling contact fatigue, and plastic deformation for a mixed traffic situation in switches and crossings (S&C) has been developed.
Kassa, Elias,, Ekh, Magnus,, Nicklisch, Dirk,, Iwnicki, Simon,, M Ekh, Ekh, Magnus, Ekh, M., Nicklisch, D., J Nielsen, Nielsen, J., E Kassa, S Iwnicki, Iwnicki, S.,, Gebretsadik, Elias Kassa,, Nielsen, Jens,, Nielsen, Jens C. O., Nielsen, Jens, Kassa, Elias, D Nicklisch, Kassa, E., Nicklisch, D.,, Iwnicki, S.   +21 more
core   +1 more source

Qualitative Analysis of Sleeper Supporting Condition for Railway Ballasted Tracks Using Modal Test

Applied Sciences
During railway operations, changes in the support conditions of sleepers, owing to various internal and external factors, can damage rails and concrete sleepers and alter the structural characteristics of gravel-ballasted tracks. However, current methods
Jung-Youl Choi, Tae Jung Yoon, Sun-Hee Kim   +2 more
doaj   +1 more source

A Validated Train-Track-Bridge Model with Nonlinear Support Conditions at Bridge Approaches

Infrastructures, 2021
A bridge approach, an essential component connecting a relatively rigid bridge and a more flexible track on subgrade soil, is one of the most common types of track transition zones.
Wenting Hou, Erol Tutumluer, Wenjing Li
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Multi-Layer Stiffness Matching of Ballastless Track for Passenger and Freight Railways: An Evaluation Method Based on Multi-Dimensional Parameter Fusion

Applied Sciences
To address the insufficient multi-layer optimization of fastener and cushion stiffness in ballastless tracks for mixed passenger and freight railways, a vehicle–track coupled dynamic model is developed, and the effects of individual and combined ...
Weibin Liu, Jijun Wang, Weitao Cui, Wenda Qin, Ruohan Yin, Chen Hua, Moyan Zhang, Yanglong Zhong   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

An investigation of sleeper voids using a flexible track model integrated with railway multi-body dynamics

, 2009
This article describes a flexible track system model (FTSM) that represents the track structure for a typical ballasted track, taking into account the flexibility of the rails, the sleeper mass and the resilience of the pad/fastening elements, as well as
Iwnicki, Simon D., Shahzad, F., Evans, G., de Vries, E., Iwnicki, S., Cavalletti, M., Bezin, Yann   +6 more
core   +1 more source

Ballastless track support deterioration evaluation using machine learning [PDF]

, 2023
Ballastless tracks have been widely used for highspeed rail systems globally since their maintenance is relatively minimal. However, support deterioration right beneath the inbetween slabs’ connectors has been usually reported and quite well known in the
Sresakoolchai, Jessada, Kaewunruen, Sakdirat; id_orcid, Li, Ting   +2 more
core   +1 more source

Evaluation of Reaction Forces on Rail-Supporting Points for Sleeper Floating Track System Using a Skin Sensor

Applied Sciences
Resilience pads provide elastic behavior and reduce impact and vibration loads in sleeper floating tracks, but their long-term degradation affects critical track components.
Jung-Youl Choi, Dae-Hui Ahn
doaj   +1 more source