Results 71 to 80 of about 1,722,613 (299)

The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection

Scientific Reports
This study was to comprehensively investigate the epidemiology of nocardiosis worldwide and develop an interpretable machine learning (ML) model to predict mortality in patients with nocardiosis.
Bingqian Du, Ziyu Song, Zhiqiang Ren, Deming Tang, Jirao Shen, Jiang Yao, Xiaotong Qiu, Shuai Xu, Min Yuan, Zhiguo Liu, Zhenjun Li   +10 more
doaj   +1 more source

Unveiling the Mutations and Conservation of InlA in Listeria monocytogenes

Microorganisms
Listeria monocytogenes (L. monocytogenes) is a pathogen that is transmitted through contaminated food and causes the illness known as listeriosis. The virulence factor InlA plays a crucial role in the invasion of L.
Lingling Li, Yan Wang, Ji Pu, Jinni Chen, Lingyun Liu, Pan Mao, Hui Sun, Xia Luo, Changyun Ye   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Optimization of the 5ʹ untranslated region of mRNA vaccines

Scientific Reports
To investigate the impact of different 5ʹ untranslated regions (UTRs) on mRNA vaccine translation efficiency, five dual-reporter gene expression plasmids with different 5ʹUTRs were constructed.
Qi Ma, Xiaoguang Zhang, Jing Yang, Hongxia Li, Yanzhe Hao, Xia Feng   +5 more
doaj   +1 more source

Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024

Frontiers in Cellular and Infection Microbiology
ObjectiveTo understand the epidemiology and evolutionary characteristics of human adenovirus (HAdV) infecting children in Yancheng, China, during the winter of 2023-2024.MethodsHAdV-positive throat swab samples were collected from pediatric patients in ...
Guoqing Chen, Jin Cao, Jin Cao, Yingli Qu, Wenyan Tian, Peng Shen, Xuan Liu, Qin Luo, Qinqin Song, Qi Wen, Guangyu Xue, Yuting Hu, Qiangqiang Shi, Lifeng Zhang, Rundong Zhu, Juan Song, Jun Han   +16 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Strain-level dynamics of Akkermansia muciniphila in the human gut microbiota

AMB Express
Akkermansia muciniphila (Akk), a mucin-degrading bacterium residing in the human gut, plays a pivotal role in intestinal health. This study investigated its temporal dynamics, strain-level diversity, and cross-regional transmission using longitudinal ...
Na Han, Xianhui Peng, Tingting Zhang, Yujun Qiang, Xiuwen Li, Wen Zhang   +5 more
doaj   +1 more source

Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters

iScience
Summary: This study explored how polymorphisms in cell surface Toll-like receptors (TLRs) influence susceptibility to Bartonella and ectoparasite infections in striped hamsters.
Xinchang Lun, Yujuan Yue, Yiguan Wang, Guichang Li, Ning Zhao, Fengxia Meng, Qiyong Liu, Pengbo Liu, Zihao Wang, Zhenxu Wang, Xiuping Song, Jun Wang, Ying Liang, Liang Lu   +13 more
doaj   +1 more source

Pinhole-coronograph tracking control [PDF]

The pinhole occulter system, a space shuttle based experiment for the production of hard X-ray images taken primarily from the Sun is described. The system is a pinhole camera utilizing a deployable 50 m flexible boom for separating the pinhole from the ...
Greene, M.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source