Results 111 to 120 of about 2,413,550 (311)

Pixel Detectors

, 2005
Pixel detectors for precise particle tracking in high energy physics have been developed to a level of maturity during the past decade. Three of the LHC detectors will use vertex detectors close to the interaction point based on the hybrid pixel ...
Wermes, Norbert
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Extra-large crystal emulsion detectors for future large-scale experiments

, 2016
Photographic emulsion is a particle tracking device which features the best spatial resolution among particle detectors. For certain applications, for example muon radiography, large-scale detectors are required.
Ariga, A., Ariga, T., Kuwabara, K., Morishima, K., Moto, M., Nishio, A., Scampoli, P., Vladymyrov, M.   +7 more
core   +1 more source

The SuperNEMO tracking detector

, 2015
The SuperNEMO detector will search for neutrinoless double beta decay at the Modane Underground Laboratory on the French-Italian border. This decay mode, if observed, would be proof that the neutrino is its own antiparticle, would constitute evidence for total lepton number violation, and could allow a measurement of the absolute neutrino mass.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cryogenic technology for tracking detectors

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001
A low-mass cryogenic cooling technique for silicon sensor modules has been developed in the framework of the RD39 Collaboration at CERN. A prototype low-mass beam tracker cryostat has been designed, constructed and tested for applications in fixed target experiments. We shall report here briefly the main features and results of the system.
V. Granata, C. da Viá, S. Watts, K. Borer, S. Janos, K. Pretzl, B. Dezillie, Z. Li, L. Casagrande, P. Collins, S. Grohmann, E. Heijne, C. Lourenço, T. O. Niinikoski, V. G. Palmieri, P. Sonderegger, BORCHI, EMILIO, BRUZZI, MARA, S. Pirollo, S. Chapuy, Z. Dimcovski, E. Grigoriev, W. Bell, S. R. H. Devine, V. O’Shea, G. Ruggiero, K. Smith, P. Berglund, W. de Boer, F. Hauler, S. Heising, L. Jungermann, M. Abreu, P. Rato Mendes, P. Sousa, V. Cindro, M. Mikuz, M. Zavrtanik, A. Esposito, I. Konorov, S. Paul, S. Buontempo, N. D’Ambrosio, S. Pagano, V. Eremin, E. Verbitskaya   +45 more
openaire   +4 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

FACIAL DETECTION IN COMPUTER VISION: BRIDGING GAP BETWEEN CNN, HAAR CASCADE AND MTCNN [PDF]

Proceedings on Engineering Sciences
Face detection is a crucial task in various applications, including face recognition, facial expression analysis, face tracking, and head-pose estimation, spanning fields such as transport, health, and education.
Nipun Singhal , Nidhi Gupta , Ajay Kumar Singh   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pixel Detectors for Charged Particles

, 2008
Pixel Detectors, as the current technology of choice for the innermost vertex detection, have reached a stage at which large detectors have been built for the LHC experiments and a new era of developments, both for hybrid and for monolithic or semi ...
Aad, Adam, Amati, Andricek, Ballin, Bettarini, Casse, Degerli, Deptuch, Dulinski, Fischer, Greiner, Kastli, Kemmer, Kenney, Kluge, Kohrs, Macchiolo, Meynants, Moll, N. Wermes, Parker, Peric, Turchetta, Velthuis, Wolf, Yarema   +26 more
core   +1 more source